Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727633 | 0.89 | LTA4H (0.38) | ABCB1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL9727700 | 0.89 | MTNR1A (0.35) | ABCB1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL9727331 | 0.87 | MTNR1A (0.37) | ABCB1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL9727762 | 0.81 | NR3C1 (0.38) | ABCB1HTR1ADRD2MAOB | |
| SCHEMBL9727464 | 0.80 | KDM4E (0.36) | — | |
| SCHEMBL9727672 | 0.72 | ABCB1 (0.43) | ABCB1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL5502488 | 0.70 | MAOA (0.40) | HTR1AADRA1DADRA1AADRA1BMAOB | |
| SCHEMBL9727777 | 0.66 | AKR1B1 (0.35) | ABCB1HTR1ADRD2 | |
| SCHEMBL21363672 | 0.63 | MAOB (0.52) | HTR1ADRD2MTNR1AMAOBMAOA | |
| SCHEMBL21363757 | 0.62 | MAOB (0.50) | MTNR1AMAOBMAOAPTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |