Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727653 | 0.87 | ABCB1 (0.38) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL9727464 | 0.81 | KDM4E (0.36) | AKR1B1 | |
| SCHEMBL9727665 | 0.80 | L3MBTL1 (0.38) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL9727633 | 0.77 | LTA4H (0.38) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL9727700 | 0.75 | MTNR1A (0.35) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL5502488 | 0.71 | MAOA (0.40) | HTR1AADRA1DADRA1AADRA1BMAOA | |
| SCHEMBL9727672 | 0.69 | ABCB1 (0.43) | MTNR1AMTNR1BHTR1AABCB1DRD2 | |
| SCHEMBL9727762 | 0.67 | NR3C1 (0.38) | HTR1AAKR1B1ABCB1DRD2MAOB | |
| SCHEMBL9727777 | 0.67 | AKR1B1 (0.35) | HTR1AAKR1B1ABCB1DRD2 | |
| SCHEMBL9727458 | 0.66 | PTGER1 (0.47) | PTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |