Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733284 | 0.83 | HTR1A (0.37) | PGRBACE1GABRA1GABRG2GABRB3 | |
| SCHEMBL9733759 | 0.82 | TDP2 (0.35) | PGRCYP11B2BACE1POLBCASP3 | |
| SCHEMBL9734356 | 0.80 | POLB (0.34) | PGRALKBACE1NSD2POLB | |
| SCHEMBL9733774 | 0.80 | HTR1A (0.38) | PGRCYP11B2CYP11B1BACE1POLB | |
| SCHEMBL9733746 | 0.80 | PGR (0.34) | PGRBACE1NSD2POLBCASP3 | |
| SCHEMBL9733259 | 0.80 | PGR (0.34) | PGRCYP11B2BACE1NSD2POLB | |
| SCHEMBL9733957 | 0.79 | CYP19A1 (0.35) | PGRCYP11B2CYP11B1BACE1POLB | |
| SCHEMBL9732964 | 0.79 | DRD2 (0.35) | PGRPDE4AALKBACE1 | |
| SCHEMBL9733966 | 0.79 | ALDH1A1 (0.33) | PGR | |
| SCHEMBL8085075 | 0.78 | PDE4A (0.41) | PDE4ADDB1CRBNCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |