Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735574 | 0.85 | BACE1 (0.32) | BACE1MEN1KMT2AALDH1A1 | |
| SCHEMBL9735728 | 0.82 | CYP11B2 (0.33) | BACE1 | |
| SCHEMBL9737011 | 0.82 | PNMT (0.34) | MAPTSMN1; SMN2ALDH1A1MAPK1CHRNB2 | |
| SCHEMBL9737251 | 0.76 | HSD17B10 (0.34) | OPRD1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL9735222 | 0.74 | RARB (0.33) | OPRD1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9735367 | 0.73 | ALOX15 (0.38) | OPRD1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL9736903 | 0.73 | OPRD1 (0.34) | OPRD1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL9736662 | 0.64 | DRD3 (0.34) | OPRD1KDM4EBACE1MEN1KMT2A | |
| SCHEMBL13163384 | 0.63 | HSP90AA1 (0.44) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL484774 | 0.62 | NPC1 (0.46) | OPRD1KDM4EMAPTBACE1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |