Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732909 | 0.85 | OPRD1 (0.35) | ALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL9735080 | 0.81 | TSHR (0.42) | HTR2CHTR2BALDH1A1KDM4ENPC1 | |
| SCHEMBL9733607 | 0.81 | DRD1 (0.35) | ALDH1A1KDM4ESIGMAR1MAPTSMN1; SMN2 | |
| SCHEMBL9733666 | 0.81 | ALDH1A1 (0.38) | SLC6A2SLC6A4ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL8088757 | 0.80 | ABCC9 (0.41) | MAOACYP1A2MAPTMEN1KMT2A | |
| SCHEMBL9733350 | 0.78 | HIF1A (0.41) | ALDH1A1MAPTSMN1; SMN2HTR2A | |
| SCHEMBL9734096 | 0.78 | ABCC9 (0.41) | CYP1A2 | |
| SCHEMBL9735453 | 0.77 | TRPV1 (0.36) | MAOACYP1A2ADRA2ASLC6A2HTR2C | |
| SCHEMBL9596387 | 0.70 | RAB9A (0.46) | CYP1A2ALDH1A1KDM4EL3MBTL1NPC1 | |
| SCHEMBL8085317 | 0.70 | MAOA (0.36) | MAOACYP1A2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |