Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974174 | 0.91 | F11 (0.40) | GAAMEN1ESR1KMT2AESR2 | |
| SCHEMBL7156677 | 0.88 | ESR1 (0.62) | GAAMEN1ESR1KMT2AESR2 | |
| SCHEMBL28119137 | 0.87 | KMT2A (0.46) | GAAMEN1KMT2AALDH1A1 | |
| Methane SCHEMBL27611186 | 0.86 | KMT2A (0.45) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL4094195 | 0.85 | ELANE (0.40) | F11ALDH1A1SMN1; SMN2ELANECISD1 | |
| SCHEMBL7932480 | 0.84 | MEN1 (0.37) | GAAMEN1ESR1KMT2AESR2 | |
| SCHEMBL7159703 | 0.80 | GAA (0.50) | GAAMEN1ESR1KMT2AESR2 | |
| Ether SCHEMBL11474697 | 0.77 | TSHR (0.44) | GAAMEN1KMT2ASLC6A4ALDH1A1 | |
| SCHEMBL18532780 | 0.76 | ELANE (0.57) | GAAMEN1ESR1KMT2AESR2 | |
| SCHEMBL10818956 | 0.76 | ESR1 (0.42) | GAAMEN1ESR1KMT2AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875412-B2 | silanetriol sulfonate complexes; for printers, copiers, facsimile machines; improved durability and environmental resistance | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| EP-1843214-A1 | Positive electrified charge control agent and positive electrified toner for developing electrostatic image | Orient Chemical Industries, Ltd. (JP) | 2007-10-10 | — | — | EP | disclosed |
| US-20070231726-A1 | Positive electrified charge control agent and positive electrified toner for developing electrostatic image | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2007-10-04 | — | — | US | disclosed |