Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.50 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 4/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 3/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7156677 | 0.89 | ESR1 (0.62) | GAAMEN1KMT2AESR1ESR2 | |
| SCHEMBL974174 | 0.88 | F11 (0.40) | GAAMEN1KMT2AESR1ESR2 | |
| SCHEMBL627133 | 0.83 | GAA (0.50) | GAAMEN1KMT2AESR1ESR2 | |
| SCHEMBL974086 | 0.80 | GAA (0.46) | GAAMEN1KMT2AESR1ESR2 | |
| SCHEMBL1937408 | 0.79 | HSD11B1 (0.51) | GAAMEN1KMT2AESR1ESR2 | |
| Hydrogen Sulfide SCHEMBL27642870 | 0.76 | KMT2A (0.81) | GAAMEN1KMT2AESR1ESR2 | |
| SCHEMBL4094195 | 0.75 | ELANE (0.40) | SMN1; SMN2ALDH1A1LMNAHTT | |
| Potassium Ion SCHEMBL11017575 | 0.74 | PTPN22 (0.44) | MEN1KMT2ALDHAMAPT | |
| SCHEMBL8321795 | 0.74 | CTSB (0.39) | GAAMEN1KMT2AESR1ESR2 | |
| SCHEMBL18316005 | 0.74 | COMT (0.55) | MEN1KMT2AIDO1CTSBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637221-B2 | Lithographic printing plate precursor, plate making method thereof and novel polymer compound | FUJIFILM CORPORATION (JP) | 2014-01-28 | — | — | US | disclosed |
| US-20130089818-A1 | LITHOGRAPHIC PRINTING PLATE PRECURSOR, PLATE MAKING METHOD THEREOF AND NOVEL POLYMER COMPOUND | FUJIFILM CORPORATION (JP) | 2013-04-11 | — | — | US | disclosed |
| US-6541178-B2 | An sulfonium(-) and iodonium(+)ion-type photoacid generator containing a naphthol structure, and photosensitive polyimide resin using photoacid generator | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2003-04-01 | — | — | US | disclosed |
| US-20020048719-A1 | Ion-type photoacid generator containing naphthol and photosensitive polyimide composition prepared by using the same | SAMSUNG ELECTRONICS CO., LTD. | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020048719-A1 | Ion-type photoacid generator containing naphthol and photosensitive polyimide composition prepared by using the same | ASIC1, H1-0, RER1 | ESR2 698/4885THRB 3875/4885GAA 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.