Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 3/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 9/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.42 |
| ▸ | HTR3B | O95264 | 6/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680491 | 0.79 | HTR3A (0.54) | ALDH1A1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL28859816 | 0.73 | MEN1 (0.46) | MEN1KMT2AALDH1A1CRHBPCRHR2 | |
| SCHEMBL1440437 | 0.71 | MEN1 (0.77) | MEN1KMT2AALDH1A1XBP1MAPK1 | |
| SCHEMBL1441135 | 0.69 | MEN1 (0.74) | MEN1KMT2AALDH1A1XBP1MAPK1 | |
| SCHEMBL27735261 | 0.67 | GAA (0.55) | MEN1KMT2AALDH1A1CRHBPCRHR2 | |
| SCHEMBL1441295 | 0.67 | MEN1 (0.66) | MEN1KMT2AALDH1A1HTR3AHTR3E | |
| SCHEMBL19691390 | 0.66 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1CRHBPCRHR2 | |
| SCHEMBL30002195 | 0.66 | KDM4E (0.61) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8152105 | 0.65 | MEN1 (0.49) | MEN1KMT2AALDH1A1CRHBPCRHR2 | |
| SCHEMBL9429631 | 0.65 | HTR3E (0.47) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494978-A1 | HETEROCYCLIC COMPOUNDS. | WYETH JOHN & BROTHER LTD (GB) | 1992-07-22 | — | — | EP | claimed |
| WO-1991005783-A1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-05-02 | — | — | WO | claimed |