SCHEMBL974956

SCHEMBL974956

Cc1nc2ncnn2c(NC(C)C(F)(F)F)c1-c1c(F)cc(F)cc1F

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 4/20 0.41
TSHR P16473 2/20 0.37
ALOX15 P16050 1/20 0.36
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL976584 0.91 MAPK1 (0.41) MAPK1TSHRALOX15HTTSMN1; SMN2
SCHEMBL8390403 0.89 ALDH1A1 (0.38) MAPK1TSHRALOX15HTTSMN1; SMN2
SCHEMBL975027 0.88 MAPK1 (0.44) MAPK1TSHRALOX15HTTSMN1; SMN2
SCHEMBL343322 0.88 MAPK1 (0.35) MAPK1TSHRALOX15MEN1GAA
SCHEMBL4484955 0.88 MAPK1 (0.35) MAPK1TSHRALOX15MEN1GAA
SCHEMBL13266845 0.88 MAPK1 (0.35) MAPK1TSHRALOX15MEN1GAA
SCHEMBL4818612 0.88 MAPK1 (0.35) MAPK1TSHRALOX15MEN1GAA
SCHEMBL976390 0.88 MAPK1 (0.35) MAPK1TSHRALOX15MEN1GAA
SCHEMBL31020398 0.86 MAPK1 (0.42) MAPK1TSHRALOX15HTTSMN1; SMN2
SCHEMBL14370113 0.85 MAPK1 (0.34) MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8974806-B2 Method for producing aqueous active substance compositions of active substances that are hardly soluble in water BASF AKTIENGESELLSCHAFT (DE) 2015-03-10 US disclosed
US-8741324-B2 Liquid pesticide compositions BASF SE (DE) 2014-06-03 US disclosed
US-8728504-B2 Process for solubilizing hydrophobic active ingredients in aqueous medium BASF SE (DE) 2014-05-20 US disclosed
EP-2676680-A1 Use of hydrophobin polypeptides as penetration enhancers BASF SE (DE) 2013-12-25 EP disclosed
US-8497230-B2 Solid crop protection agents containing polyalkoxylate, method for their production and use thereof BASF AKTIENGESELLSCHAFT (DE) 2013-07-30 US disclosed
US-20130123108-A1 ACTIVE SUBSTANCE COMPOSITION COMPRISING AT LEAST ONE NITROGEN ATOM-CONTAINING, HYPERBRANCHED POLYMER BASF SE (DE) 2013-05-16 US disclosed
EP-1763300-B1 USE OF ETHER GROUP-CONTAINING POLYMERS AS SOLUBILIZERS BASF SE (DE) 2013-05-15 EP disclosed
US-20110312497-A1 USE OF HYDROPHOBIN AS A SPREADING AGENT BASF SE (DE) 2011-12-22 US disclosed
US-20110195844-A1 PROCESS FOR SOLUBILIZING HYDROPHOBIC ACTIVE INGREDIENTS IN AQUEOUS MEDIUM BASF SE (DE) 2011-08-11 US disclosed
EP-1773121-B1 LIQUID PESTICIDE COMPOSITIONS BASF SE (DE) 2011-02-09 EP disclosed
US-20080192251-A1 Method For Determining Residues in Plastics BASF AKTIENGESELLSCHAFT (DE) 2008-08-14 US disclosed
US-20080167189-A1 Polymer Compositions and Their Use in the Production of Active or Effective Ingredient Compositions BASF AKTIENGESELLSCHAFT (DE) 2008-07-10 US disclosed
EP-1776010-B1 METHOD FOR PRODUCING AQUEOUS ACTIVE SUBSTANCE COMPOSITIONS OF ACTIVE SUBSTANCES THAT ARE HARDLY SOLUBLE IN WATER BASF AG (DE) 2007-12-26 EP disclosed
EP-1756188-B1 AMPHIPHILIC POLYMER COMPOSITIONS AND THEIR USE BASF AG (DE) 2007-12-05 EP disclosed
US-20070184983-A1 Liquid pesticide compositions BASF SE (DE) 2007-08-09 US disclosed
EP-1776010-A2 METHOD FOR PRODUCING AQUEOUS ACTIVE SUBSTANCE COMPOSITIONS OF ACTIVE SUBSTANCES THAT ARE HARDLY SOLUBLE IN WATER BASF AKTIENGESELLSCHAFT (DE) 2007-04-25 EP disclosed
EP-1773121-A1 LIQUID PESTICIDE COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 2007-04-18 EP disclosed
WO-2006015791-A2 METHOD FOR PRODUCING AQUEOUS ACTIVE SUBSTANCE COMPOSITIONS OF ACTIVE SUBSTANCES THAT ARE HARDLY SOLUBLE IN WATER BASF AKTIENGESELLSCHAFT (DE) 2006-02-16 WO disclosed
WO-2006002984-A1 LIQUID PESTICIDE COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 2006-01-12 WO disclosed
US-5994360-A Fungicidal 5-alkyl-triazolopyrimidines AMERICAN CYANAMID COMPANY (US) 1999-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312497-A1 USE OF HYDROPHOBIN AS A SPREADING AGENT PFN1, DSTN, CHN2 MAPK1 3589/4885TSHR 4646/4885ALOX15 2818/4885
US-20110195844-A1 PROCESS FOR SOLUBILIZING HYDROPHOBIC ACTIVE INGREDIENTS IN AQUEOUS MEDIUM IDUA, PHOSPHO1, HDHD5 MAPK1 477/4885TSHR 4465/4885ALOX15 757/4885
US-20080167189-A1 Polymer Compositions and Their Use in the Production of Active or Effective Ingredient Compositions GANC, PHOSPHO1, PGLS MAPK1 2104/4885TSHR 4882/4885ALOX15 2841/4885
US-20130123108-A1 ACTIVE SUBSTANCE COMPOSITION COMPRISING AT LEAST ONE NITROGEN ATOM-CONTAINING, HYPERBRANCHED POLYMER NOS1, NOS3, NPSR1 MAPK1 2382/4885TSHR 3493/4885ALOX15 2950/4885
US-20070184983-A1 Liquid pesticide compositions CBR3, BBC3, DDT MAPK1 2845/4885TSHR 992/4885ALOX15 1054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.