Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyriphenop. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | APEX1 | P27695 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clodinafop SCHEMBL9792036 | 0.88 | LMNA (0.55) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| Pyriphenop SCHEMBL134252 | 0.87 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| Pyriphenop SCHEMBL29419117 | 0.87 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| SCHEMBL9421448 | 0.87 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| Pyriphenop SCHEMBL8081008 | 0.87 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| SCHEMBL10616094 | 0.87 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| Pyriphenop SCHEMBL10824511 | 0.86 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| SCHEMBL11075547 | 0.86 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| Pyriphenop SCHEMBL10727244 | 0.86 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 | |
| Pyriphenop SCHEMBL11012717 | 0.86 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2LMNAAPEX1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4280832-A | Pyridyloxy-phenoxyalkane carboxylic acids and derivatives as sugar enhancers for plants | UNION CARBIDE CORPORATION (US) | 1981-07-28 | — | — | US | claimed |
| JP-61103805-A | — | — | None | — | — | JP | disclosed |
| US-5073188-A | Herbicidal amides of 4-trifluoromethyl-3'-carboxyl-4'-nitrodiphenyl ethers | ROHM AND HAAS COMPANY (US) | 1991-12-17 | — | — | US | disclosed |
| US-4937381-A | Herbicidal amides of 4-trifluoromethyl-3'-carboxyl-4'-nitro-diphenyl ethers | ROHM AND HAAS COMPANY (US) | 1990-06-26 | — | — | US | disclosed |
| JP-S61103805-A | HERBICIDAL COMPOSITION | SUMITOMO CHEM CO LTD | 1986-05-22 | — | — | JP | disclosed |