Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799815 | 0.88 | L3MBTL1 (0.35) | NPC1KCNH2L3MBTL1 | |
| SCHEMBL9799313 | 0.81 | TUBB4A (0.38) | CYP1A2CYP2C9CYP2C19L3MBTL1MEN1 | |
| SCHEMBL9799434 | 0.74 | MEN1 (0.38) | NPC1CYP1A2CYP2C9CYP2C19CHRM2 | |
| SCHEMBL9799280 | 0.74 | SIGMAR1 (0.40) | NPC1CYP1A2CYP2C9CYP2C19CHRM2 | |
| SCHEMBL9832379 | 0.73 | NPC1 (0.35) | NPC1CYP1A2CYP2C9CYP2C19ESR1 | |
| SCHEMBL9833650 | 0.72 | MAPT (0.41) | NPC1L3MBTL1KMT2A | |
| SCHEMBL13307925 | 0.68 | L3MBTL1 (0.41) | CHRM2CHRM1HTR1AADRA2ADRD1 | |
| SCHEMBL9799541 | 0.67 | PTGS2 (0.39) | CYP1A2CYP2C9CYP2C19L3MBTL1MEN1 | |
| SCHEMBL5914943 | 0.64 | SMN1; SMN2 (0.43) | NPC1CYP1A2CYP2C9CYP2C19CHRM2 | |
| SCHEMBL5915004 | 0.64 | SMN1; SMN2 (0.43) | NPC1CYP1A2CYP2C9CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298703-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4946862-A | Thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0298703-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-11 | — | — | EP | disclosed |