Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 4/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799293 | 0.88 | FDPS (0.38) | SIGMAR1KCNH2AOC3FDPSNPC1 | |
| SCHEMBL9799232 | 0.80 | OPRM1 (0.40) | CHRM2SLC6A4OPRM1SLC6A3KCNH2 | |
| SCHEMBL9799267 | 0.80 | CYP3A4 (0.46) | CHRM2HTR1AADRA2ADRD1SLC6A4 | |
| SCHEMBL10423292 | 0.80 | KDM4E (0.41) | CHRM2SLC6A4OPRM1SLC6A3KCNH2 | |
| SCHEMBL9799434 | 0.75 | MEN1 (0.38) | SIGMAR1CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL9830678 | 0.74 | RIPK1 (0.38) | CHRM2CHRM1 | |
| SCHEMBL9799824 | 0.74 | NPC1 (0.35) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL9849846 | 0.71 | ALDH1A1 (0.36) | SIGMAR1SLC6A2SLC6A4ADRA1ASLC6A3 | |
| SCHEMBL9831796 | 0.69 | NPC1 (0.35) | NPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16268640 | 0.69 | MAOA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298703-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-06 | — | — | EP | claimed |
| US-4946862-A | Thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1990-08-07 | — | — | US | claimed |
| EP-0298703-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-11 | — | — | EP | claimed |
| JP-2256613-A | — | — | None | — | — | JP | disclosed |
| EP-0298703-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| JP-H02256613-A | REGULATOR FOR DIGESTIVE TRACT FUNCTION | TANABE SEIYAKU CO LTD | 1990-10-17 | — | — | JP | disclosed |
| US-4946862-A | Thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0298703-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-11 | — | — | EP | disclosed |