SCHEMBL9834580

SCHEMBL9834580

CC(C)N(CCNC1Oc2ccccc2Cc2cccnc21)C(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
HTR1A P08908 3/20 0.35
HTR1D P28221 3/20 0.35
HSP90AA1 P07900 1/20 0.34
HSP90AB1 P08238 1/20 0.34
SIGMAR1 Q99720 1/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31
CXCR4 P61073 1/20 0.31
HTR2C P28335 1/20 0.30
SLC22A2 O15244 1/20 0.30
SLC22A1 O15245 1/20 0.30
PGR P06401 1/20 0.30
THRB P10828 1/20 0.30
ADRB3 P13945 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9836638 0.87 CYP2C19 (0.41) HRH1CHRM2CHRM4CHRM5CHRM1
SCHEMBL9835190 0.85 HTR1A (0.35) HRH1CHRM2CHRM4CHRM5CHRM1
SCHEMBL9835645 0.81 ALDH1A1 (0.37) HRH1CHRM2CHRM4CHRM5CHRM1
SCHEMBL9836563 0.76 ADRA2C (0.36) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9837035 0.76 OPRL1 (0.42) HTR1AHTR1DCXCR4CYP3A4
SCHEMBL9836619 0.75 CXCR4 (0.42) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9836246 0.71 MTNR1A (0.40) HTR1AHTR1DTSHR
SCHEMBL11016897 0.71 CYP2C19 (0.36) HRH1CHRM2CHRM4CHRM5CHRM1
SCHEMBL9836832 0.70 ALDH1A1 (0.34) BLMCYP3A4TSHRTDP1
SCHEMBL11010608 0.70 OPRL1 (0.33) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0129879-B1 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-09-11 EP claimed
US-4547496-A Antiulcer [1] benzepino[3,4-b]pyridine and compositions KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-10-15 US claimed
EP-0129879-A2 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-01-02 EP claimed
EP-0129879-B1 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-09-11 EP disclosed
US-4547496-A Antiulcer [1] benzepino[3,4-b]pyridine and compositions KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-10-15 US disclosed