SCHEMBL9836638

SCHEMBL9836638

CN(C)CCNC1Oc2ccccc2Cc2cccnc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.41
HTR1A P08908 4/20 0.37
HTR1D P28221 3/20 0.37
HRH1 P35367 7/20 0.35
HTR2A P28223 4/20 0.35
CHRM2 P08172 3/20 0.35
CHRM4 P08173 3/20 0.35
CHRM5 P08912 3/20 0.35
CHRM1 P11229 3/20 0.35
ALDH1A1 P00352 3/20 0.35
KCNH2 Q12809 2/20 0.35
HTR2B P41595 2/20 0.35
CHRM3 P20309 2/20 0.35
SLC22A1 O15245 1/20 0.35
ADRA2A P08913 1/20 0.35
DRD2 P14416 1/20 0.35
ADRA2B P18089 1/20 0.35
ADRA2C P18825 1/20 0.35
DRD1 P21728 1/20 0.35
DRD4 P21917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9835190 0.88 HTR1A (0.35) HTR1AHTR1DHRH1HTR2ACHRM2
SCHEMBL9834580 0.87 HRH1 (0.36) HTR1AHTR1DHRH1CHRM2CHRM4
SCHEMBL9835645 0.84 ALDH1A1 (0.37) HTR1AHTR1DHRH1HTR2ACHRM2
SCHEMBL11016897 0.83 CYP2C19 (0.36) CYP2C19HRH1HTR2ACHRM2CHRM4
SCHEMBL9836563 0.79 ADRA2C (0.36) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9837035 0.78 OPRL1 (0.42) HTR1AHTR1DLMNACYP2D6
SCHEMBL9836619 0.77 CXCR4 (0.42) CYP2C19CHRM2CHRM4CHRM5CHRM1
SCHEMBL9836246 0.74 MTNR1A (0.40) HTR1AHTR1DALDH1A1LMNATSHR
SCHEMBL11010608 0.72 OPRL1 (0.33) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9836832 0.72 ALDH1A1 (0.34) ALDH1A1LMNATSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0129879-B1 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-09-11 EP claimed
US-4547496-A Antiulcer [1] benzepino[3,4-b]pyridine and compositions KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-10-15 US claimed
EP-0129879-A2 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-01-02 EP claimed
US-4547496-A Antiulcer [1] benzepino[3,4-b]pyridine and compositions KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-10-15 US disclosed