Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835822 | 0.85 | CYP2C9 (0.46) | RORCCA12CA1CA2CA9 | |
| SCHEMBL10693476 | 0.83 | CA2 (0.49) | CA1CA2ALDH1A1SMN1; SMN2LMNA | |
| Risotilide SCHEMBL123045 | 0.83 | TRPV4 (0.49) | RORCCA12CA1CA2CA9 | |
| Risotilide SCHEMBL635829 | 0.82 | LMNA (0.49) | RORCCA12CA1CA2CA9 | |
| SCHEMBL8864040 | 0.81 | CYP2C9 (0.44) | RORCCA12CA1CA2CA9 | |
| SCHEMBL10773767 | 0.80 | HTT (0.64) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL10679045 | 0.78 | GAA (0.42) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL10693087 | 0.78 | TDP1 (0.46) | ALDH1A1MAPTTSHRHTTKEAP1 | |
| SCHEMBL10692230 | 0.77 | ALDH1A1 (0.65) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL12054668 | 0.69 | KEAP1 (0.75) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260901-B1 | BENZENESULPHONAMIDES USEFUL AS ANTI-ARRYTHMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-03-06 | — | — | EP | claimed |
| US-4721809-A | Alkylsulfonamido or perfluoroalkylsulfonamido benzenesulfonamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-26 | — | — | US | claimed |
| EP-0260901-B1 | BENZENESULPHONAMIDES USEFUL AS ANTI-ARRYTHMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0260901-A1 | Benzenesulphonamides useful as anti-arrythmic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-03-23 | — | — | EP | disclosed |
| US-4721809-A | Alkylsulfonamido or perfluoroalkylsulfonamido benzenesulfonamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |