SCHEMBL9854622

SCHEMBL9854622

C[C@H]1CC[C@H]2C(C)(CO)C(O)CC[C@]2(C)[C@@]12CC[C@](CO)(CC(=O)[O-])O2.[Na+]

nearest known ligand 0.71

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.71
MEN1 O00255 1/20 0.71
KMT2A Q03164 1/20 0.71
POLA1 P09884 3/20 0.36
LMNA P02545 2/20 0.36
HTT P42858 1/20 0.36
RECQL P46063 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HIF1A Q16665 1/20 0.36
PTPN1 P18031 7/20 0.34
F3 P13726 3/20 0.34
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
CYP2C19 P33261 1/20 0.34
USP2 O75604 1/20 0.32
USP7 Q93009 1/20 0.32
SLCO1B3 Q9NPD5 1/20 0.32
SLCO1B1 Q9Y6L6 1/20 0.32
ST6GAL1 P15907 1/20 0.30
FUT6 P51993 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lagochiline SCHEMBL9854640 0.83 CYP3A4 (1.00) CYP3A4MEN1KMT2APOLA1LMNA
SCHEMBL9854657 0.75 CYP3A4 (0.62) CYP3A4MEN1KMT2APOLA1LMNA
SCHEMBL9854626 0.60
Aphidicolin SCHEMBL8763668 0.53 POLA1 (1.00) CYP3A4MEN1KMT2APOLA1LMNA
Aphidicolin SCHEMBL14667945 0.53 POLA1 (1.00) CYP3A4MEN1KMT2APOLA1LMNA
SCHEMBL12228795 0.50 NR1H4 (0.55) CYP3A4MEN1KMT2APOLA1LMNA
SCHEMBL30828824 0.49 CA4 (0.35)
SCHEMBL11870137 0.47 ALOX15 (0.66) CYP3A4MEN1KMT2APOLA1LMNA
SCHEMBL18789463 0.46 ALDH1A1 (0.36) CYP3A4MEN1KMT2ALMNA
Hexacyclonate SCHEMBL1641659 0.46 USP2 (0.41) LMNASMN1; SMN2CYP2C19USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0408749-A1 DERIVATIVES OF 3,18-DIHYDROXY-9,13-EPOXYLABDANE, METHOD OF OBTAINING THEM AND A HEMOSTATIC PHARMACEUTICAL PREPARATION BASED THEREON TASHKENTSKY GOSUDARSTVENNY UNIVERSITET IMENI V.I. LENINA (SU) 1991-01-23 EP claimed
EP-0408749-A1 DERIVATIVES OF 3,18-DIHYDROXY-9,13-EPOXYLABDANE, METHOD OF OBTAINING THEM AND A HEMOSTATIC PHARMACEUTICAL PREPARATION BASED THEREON TASHKENTSKY GOSUDARSTVENNY UNIVERSITET IMENI V.I. LENINA (SU) 1991-01-23 EP disclosed