Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9874662 | 0.86 | SCN3A (0.39) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL9874743 | 0.78 | LMNA (0.51) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL8683970 | 0.77 | ALDH1A1 (0.56) | TSHRMAPTGAAMAPK1ALDH1A1 | |
| SCHEMBL8683966 | 0.77 | ALDH1A1 (0.56) | TSHRMAPTGAAMAPK1ALDH1A1 | |
| SCHEMBL9873593 | 0.76 | DRD2 (0.57) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL9873677 | 0.76 | KDM4E (0.47) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL9872533 | 0.74 | DRD2 (0.49) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL9873084 | 0.73 | PDK1 (0.66) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL18901617 | 0.72 | ALDH1A1 (0.55) | TSHRMAPTGAAHTTMAPK1 | |
| SCHEMBL9875015 | 0.69 | DRD2 (0.57) | TSHRMAPTGAAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988699-A | Treatment of psychological disorders such as schizophrenia, as antipsychotic agents and hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | disclosed |