Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8183561 | 0.86 | ALDH1A1 (0.40) | POLBSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL5353299 | 0.85 | LMNA (0.45) | KMT2AMEN1SMN1; SMN2GAAHTT | |
| SCHEMBL6623489 | 0.83 | KMT2A (0.45) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL62021 | 0.80 | POLB (0.53) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL23908020 | 0.79 | POLB (0.41) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL2387324 | 0.79 | ADORA3 (0.48) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL23884134 | 0.79 | NUDT1 (0.44) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL23884245 | 0.79 | KMT2A (0.49) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL9019845 | 0.78 | POLB (0.40) | POLBKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL6629111 | 0.78 | RXRA (0.44) | KMT2AMEN1SMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171116-A4 | METHOD FOR THE PREVENTION OR REDUCTION OF CARIOVASCULAR EVENTS ASSOCIATED WITH CORONARY INTERVENTION | SMITHKLINE BEECHAM CORP (US) | 2004-11-17 | — | — | EP | claimed |
| EP-1171116-A1 | METHOD FOR THE PREVENTION OR REDUCTION OF CARIOVASCULAR EVENTS ASSOCIATED WITH CORONARY INTERVENTION | SmithKline Beecham Corporation (US) | 2002-01-16 | — | — | EP | claimed |
| WO-2000045811-A1 | METHOD FOR THE PREVENTION OR REDUCTION OF CARIOVASCULAR EVENTS ASSOCIATED WITH CORONARY INTERVENTION | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-10 | — | — | WO | claimed |
| WO-2000046212-A1 | METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-08-10 | — | — | WO | claimed |
| WO-2025264954-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2025-12-26 | — | — | WO | disclosed |
| CN-118164965-A | Pyrimidine-triazole-fluorine substituted phenyl cyclopropylamine derivative and application thereof | 郑州大学 | 2024-06-11 | — | — | CN | disclosed |
| US-20240182450-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | OREGON HEALTH AND SCIENCE UNIVERSITY | 2024-06-06 | — | — | US | disclosed |
| US-11932626-B2 | 2-pyrimidone analogs as potent antiviral agents against Alphaviruses | SOUTHERN RESEARCH INSTITUTE (US) | 2024-03-19 | — | — | US | disclosed |
| CN-117586280-A | KRAS G12D inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| US-20230120566-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | OREGON HEALTH AND SCIENCE UNIVERSITY | 2023-04-20 | — | — | US | disclosed |
| US-20230120566-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | OREGON HEALTH AND SCIENCE UNIVERSITY | 2023-04-20 | — | — | US | disclosed |
| CN-115916175-A | Novel 2-pyrimidinone analogs as potent antiviral agents against alphaviruses | 南方研究院 | 2023-04-04 | — | — | CN | disclosed |
| WO-2004063192-A1 | IMIDAZOLYL PYRIMIDINE DERIVATIVES USEFUL AS IL-8 RECEPTOR MODULATORS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| US-6537948-B1 | Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-03-25 | — | — | US | disclosed |
| EP-1122244-A1 | Uracil compounds and their use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000046212-A1 | METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-08-10 | — | — | WO | disclosed |
| US-5723412-A | HERBICIDES | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1998-03-03 | — | — | US | disclosed |
| US-5599770-A | WEED CONTROL; INCLUDING AN ADJUVANT | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1997-02-04 | — | — | US | disclosed |
| EP-0694538-A2 | 2-benzyloxy-4-phenoxypyrimidine derivative, processes for producing the derivative and herbicidal composition containing the derivative | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-01-31 | — | — | EP | disclosed |
| EP-0692477-A1 | Herbicidal compositions containing 2-benzyloxypyrimidine derivatives | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11932626-B2 | 2-pyrimidone analogs as potent antiviral agents against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | POLB 2683/4885KMT2A 2117/4885MEN1 4254/4885 |
| US-20240182450-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | POLB 2855/4885KMT2A 2305/4885MEN1 4347/4885 |
| US-20230120566-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | POLB 2855/4885KMT2A 2305/4885MEN1 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.