Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924129 | 0.82 | TRPV1 (0.39) | TRPV1MRGPRX4EPHX2MAPK11MAPK14 | |
| SCHEMBL9924231 | 0.82 | LMNA (0.41) | TRPV1MRGPRX4EPHX2ALDH1A1MAPK11 | |
| SCHEMBL9924262 | 0.82 | UBE2M (0.46) | TRPV1MRGPRX4EPHX2ALDH1A1 | |
| SCHEMBL17206709 | 0.81 | TRPV1 (0.42) | TRPV1MRGPRX4EPHX2ALDH1A1 | |
| SCHEMBL9924227 | 0.80 | EPHX2 (0.52) | EPHX2 | |
| SCHEMBL9924261 | 0.79 | TRPV1 (0.42) | TRPV1MRGPRX4CRHR1EPHX2ALDH1A1 | |
| SCHEMBL17206706 | 0.78 | DCUN1D1 (0.52) | EPHX2 | |
| SCHEMBL19362654 | 0.75 | TRPV1 (0.42) | TRPV1MRGPRX4CRHR1EPHX2MAPK11 | |
| SCHEMBL9924230 | 0.73 | MCHR1 (0.40) | EPHX2 | |
| SCHEMBL9924130 | 0.73 | DCUN1D1 (0.52) | MRGPRX4EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |