Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832991 | 0.78 | GSTO1 (0.34) | GPR119 | |
| SCHEMBL28702674 | 0.78 | GPR119 (0.43) | GPR119 | |
| SCHEMBL12822609 | 0.75 | KDM4E (0.36) | ALDH1A1TRPM8 | |
| SCHEMBL1163820 | 0.75 | PAX8 (0.41) | PAX8GPR119ALDH1A1BRD4GBA1 | |
| SCHEMBL29067294 | 0.75 | GPR119 (0.37) | GPR119 | |
| SCHEMBL4832540 | 0.75 | NFKB1 (0.36) | GPR119ALDH1A1TRPM8 | |
| SCHEMBL3737254 | 0.73 | PAX8 (0.40) | PAX8ALDH1A1USP30BRD4 | |
| SCHEMBL3867522 | 0.73 | TRPM8 (0.38) | TRPM8 | |
| SCHEMBL2659089 | 0.70 | PDK2 (0.40) | GPR119ALDH1A1USP30GBA1 | |
| SCHEMBL7329772 | 0.70 | TRPM8 (0.40) | GPR119USP30TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | HARRIS III RALPH NEW (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | P2RX7, P2RX3, P2RX1 | PAX8 3760/4885GPR119 27/4885ALDH1A1 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.