Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 6/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.45 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954119 | 0.87 | HCAR1 (0.52) | HCAR1 | |
| SCHEMBL9954505 | 0.84 | PDE7A (0.45) | PDE7APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9954005 | 0.84 | HCAR1 (0.40) | PDE4DHCAR1 | |
| SCHEMBL9954657 | 0.82 | HPD (0.44) | HCAR1 | |
| SCHEMBL9954224 | 0.81 | CDK9 (0.38) | PDE4DHCAR1DYRK1A | |
| SCHEMBL9954457 | 0.81 | HCAR1 (0.50) | HCAR1 | |
| SCHEMBL9953129 | 0.80 | POLB (0.41) | HCAR1 | |
| SCHEMBL9953879 | 0.80 | GLA (0.51) | — | |
| SCHEMBL9953534 | 0.79 | HCAR1 (0.43) | PDE4DHCAR1 | |
| SCHEMBL9952976 | 0.78 | LMNA (0.45) | HCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |