Ilomastat

Ilomastat

SCHEMBL29412562

CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CC(=O)NO)CC(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 16/20 1.00
▸ MMP9 P14780 16/20 1.00
▸ MMP8 P22894 14/20 1.00
▸ MMP1 P03956 7/20 1.00
▸ MMP3 P08254 3/20 1.00
▸ MMP14 P50281 2/20 1.00
▸ ADAM10 O14672 1/20 1.00
▸ ADAM12 O43184 1/20 1.00
▸ ADAMTS4 O75173 1/20 1.00
▸ MMP7 P09237 1/20 1.00
▸ MMP12 P39900 1/20 1.00
▸ MMP13 P45452 1/20 1.00
▸ MMP15 P51511 1/20 1.00
▸ MMP16 P51512 1/20 1.00
▸ ADAM17 P78536 1/20 1.00
▸ ADAM9 Q13443 1/20 1.00
▸ MMP26 Q9NRE1 1/20 1.00
▸ MMP17 Q9ULZ9 1/20 1.00
▸ ADAMTS5 Q9UNA0 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ilomastat SCHEMBL6691646 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
Ilomastat SCHEMBL4293696 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
Ilomastat SCHEMBL4394885 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
Ilomastat SCHEMBL7870487 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
Ilomastat SCHEMBL13575799 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
Ilomastat SCHEMBL8190117 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
Ilomastat SCHEMBL35303 1.00 MMP2 (1.00) MMP2MMP9MMP8MMP1MMP3
SCHEMBL8394283 0.92 MMP2 (0.85) MMP2MMP9MMP8MMP1MMP3
SCHEMBL4845965 0.91 MMP2 (0.84) MMP2MMP9MMP8MMP1MMP3
SCHEMBL5558468 0.90 MMP2 (0.82) MMP2MMP9MMP8MMP1MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4058037-B1 FIBROBLAST-BASED THERAPY FOR TREATMENT AND PREVENTION OF STROKE SPINALCYTE LLC (US) 2026-01-28 — — EP claimed
US-20250332225-A1 Injectable Neutral pH Collagen-Based Composition For Mesotherapy SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD (CN) 2025-10-30 — — US claimed
EP-3866936-B1 COSMETIC COMPOSITION WITH AN IMPROVED PICKUP UNILEVER IP HOLDINGS B V (NL) 2024-03-06 — — EP claimed
EP-3980477-B1 A POLYMER AND A COSMETIC COMPOSITION COMPRISING THE POLYMER UNILEVER IP HOLDINGS B V (NL) 2023-01-04 — — EP claimed
US-20220370506-A1 AUGMENTATION OF FIBROBLAST MEDIATED REGENERATION OF INTRAVERTEBRAL DISCS FIGENE, LLC 2022-11-24 — — US claimed
EP-4081261-A1 AUGMENTATION OF FIBROBLAST MEDIATED REGENERATION OF INTRAVERTEBRAL DISCS Figene, LLC (US) 2022-11-02 — — EP claimed
US-20260133193-A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES UNIVERSITY OF WASHINGTON (US) 2026-05-14 — — US disclosed
US-20260115231-A1 TREATMENT OF CEREBRAL PALSY USING FIBROBLASTS SPINALCYTE LLC (US) 2026-04-30 — — US disclosed
EP-4058037-B1 FIBROBLAST-BASED THERAPY FOR TREATMENT AND PREVENTION OF STROKE SPINALCYTE LLC (US) 2026-01-28 — — EP disclosed
US-12508287-B2 Treatment of cerebral palsy using fibroblasts SPINALCYTE LLC (US) 2025-12-30 — — US disclosed
US-20250382240-A1 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SALARIUS PHARMACEUTICALS INC (US) 2025-12-18 — — US disclosed
US-20250332225-A1 Injectable Neutral pH Collagen-Based Composition For Mesotherapy SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD (CN) 2025-10-30 — — US disclosed
US-20250288724-A1 METHODS AND MATERIALS FOR USING FIBRIN SUPPORTS FOR RETINAL PIGMENT EPITHELIUM TRANSPLANTATION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2025-09-18 — — US disclosed
WO-2022096789-A1 HICA FOR USE IN PROPHYLAXIS AND/OR TREATMENT OF A DISEASE OR CONDITION INVOLVING DEGRADATION OF CARTILAGE AND/OR DISRUPTION OF CARTILAGE HOMEOSTASIS AND/OR INTEGRITY SALARUSTA OY (FI) 2022-05-12 — — WO disclosed
CN-114375291-A Novel compounds for skin lightening 联合利华知识产权控股有限公司 2022-04-19 — — CN disclosed
CN-114341100-A Novel compounds for skin lightening 联合利华知识产权控股有限公司 2022-04-12 — — CN disclosed
US-20220098128-A1 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTEROPIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SALARIUS PHARMACEUTICALS, INC. 2022-03-31 — — US disclosed
US-11286251-B2 Matrix metalloproteinase inhibitors and imaging agents, and methods using same YALE UNIVERSITY (US) 2022-03-29 — — US disclosed
CN-216055870-U Distribution automation equipment electric automatization detection device 范圣奇 2022-03-15 — — CN disclosed
WO-2022047486-A2 DENTAL AND PERIODONTAL APPLICATION OF FIBROBLASTS FIGENE, LLC (US) 2022-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11286251-B2 Matrix metalloproteinase inhibitors and imaging agents, and methods using same MMP3, MMP1, MMP10 MMP2 13/4885MMP9 8/4885MMP8 16/4885
US-20260133193-A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES FCGR3B, FCGR2A, FCGR1A MMP2 706/4885MMP9 489/4885MMP8 42/4885
US-20250382240-A1 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME IL5, TLR5, IDO1 MMP2 3466/4885MMP9 2402/4885MMP8 971/4885
US-20220098128-A1 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTEROPIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME IL5, IL15, CXCR5 MMP2 3226/4885MMP9 2323/4885MMP8 851/4885
US-12508287-B2 Treatment of cerebral palsy using fibroblasts PGF, CRH, HIF1A MMP2 903/4885MMP9 2200/4885MMP8 207/4885
US-20260115231-A1 TREATMENT OF CEREBRAL PALSY USING FIBROBLASTS PGF, FGF2, FGF1 MMP2 769/4885MMP9 1002/4885MMP8 363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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