Sugi Predict

Sugi Predict / Compounds / SCHEMBL1002345

SCHEMBL1002345

SCHEMBL1002345

CCc1sc(N)nc1C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ COPS5 Q92905 9/20 0.54
▸ ALDH1A1 P00352 5/20 0.46
▸ MAPT P10636 1/20 0.46
▸ CYP1A2 P05177 3/20 0.45
▸ FBP1 P09467 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ HRH2 P25021 1/20 0.36
▸ HRH1 P35367 1/20 0.36
▸ HRH4 Q9H3N8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL7136559 0.98 COPS5 (0.52) COPS5ALDH1A1MAPTCYP1A2FBP1
SCHEMBL5217772 0.85 FBP1 (0.58) COPS5ALDH1A1MAPTCYP1A2FBP1
SCHEMBL1758948 0.85 ALDH1A1 (0.44) COPS5ALDH1A1MAPTCYP1A2FBP1
SCHEMBL1034370 0.81 COPS5 (0.54) COPS5ALDH1A1CYP1A2FBP1HRH2
SCHEMBL535765 0.80 L3MBTL1 (0.56) COPS5ALDH1A1MAPTCYP1A2FBP1
SCHEMBL30567598 0.80 COPS5 (0.57) COPS5ALDH1A1CYP1A2FBP1KDM4E
SCHEMBL31661235 0.79 ALDH1A1 (0.69) ALDH1A1MAPTCYP1A2FBP1L3MBTL1
SCHEMBL1548680 0.78 COPS5 (0.40) COPS5ALDH1A1L3MBTL1SMN1; SMN2MEN1
SCHEMBL22774382 0.78 L3MBTL1 (0.40) COPS5ALDH1A1FBP1L3MBTL1KMT2A
SCHEMBL3838148 0.78 L3MBTL1 (0.43) COPS5ALDH1A1MAPTL3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases MASARYKOVA UNIVERZITA (CZ) 2023-02-21 — — US disclosed
US-20230026651-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS CYTOKINETICS, INC. 2023-01-26 — — US disclosed
US-11369565-B2 Amino-pyrimidine skeletal muscle modulators CYTOKINETICS, INC. (US) 2022-06-28 — — US disclosed
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2022-01-06 — — US disclosed
EP-3556755-B1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2021-11-17 — — EP disclosed
US-20210045997-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS CYTOKINETICS, INC. 2021-02-18 — — US disclosed
CN-112047926-A Certain amino-pyrimidines, compositions thereof and methods of use thereof 赛特凯恩蒂克公司 2020-12-08 — — CN disclosed
US-10765624-B2 Amino-pyrimidine skeletal muscle modulators CYTOKINETICS, INC. (US) 2020-09-08 — — US disclosed
EP-3698795-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE Cytokinetics, Inc. (US) 2020-08-26 — — EP disclosed
CN-105712974-B Certain amino-pyrimidines, compositions thereof and methods of use thereof 赛特凯恩蒂克公司 2020-07-31 — — CN disclosed
US-5811411-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1998-09-22 — — US disclosed
EP-0700394-B1 HERBICIDAL THIAZOLE DERIVATIVES SHELL INT RESEARCH (NL) 1998-04-01 — — EP disclosed
US-5705513-A HETEROCYCLIC FUNGICIDES WITH PYRIDINE OR FURAN RINGS MONSANTO COMPANY (US) 1998-01-06 — — US disclosed
US-5693594-A Herbicidal thiazole derivatives AMERICAN CYANAMID COMPANY (US) 1997-12-02 — — US disclosed
US-5693667-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1997-12-02 — — US disclosed
EP-0700394-A1 HERBICIDAL THIAZOLE DERIVATIVES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1996-03-13 — — EP disclosed
US-5498630-A SUBSTITUTED BENZOTHIOPHENECARBOXAMIDES MONSANTO COMPANY (US) 1996-03-12 — — US disclosed
WO-1994027983-A1 HERBICIDAL THIAZOLE DERIVATIVES SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1994-12-08 — — WO disclosed
WO-1993007751-A1 FUNGICIDES FOR THE CONTROL OF TAKE-ALL DISEASE OF PLANTS MONSANTO COMPANY (US) 1993-04-29 — — WO disclosed
EP-0538231-A1 Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1993-04-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11369565-B2 Amino-pyrimidine skeletal muscle modulators MUSK, PYGM, TNNC1 COPS5 2383/4885ALDH1A1 2521/4885MAPT 4234/4885
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases RNASEH1, DNASE1, FEN1 COPS5 3600/4885ALDH1A1 2267/4885MAPT 706/4885
US-10765624-B2 Amino-pyrimidine skeletal muscle modulators MUSK, PYGM, TNNC1 COPS5 1356/4885ALDH1A1 3068/4885MAPT 4151/4885
US-20230026651-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS MUSK, PYGM, TNNC1 COPS5 1356/4885ALDH1A1 3068/4885MAPT 4151/4885
US-20210045997-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS MUSK, PYGM, TNNC1 COPS5 2383/4885ALDH1A1 2521/4885MAPT 4234/4885
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES RNASEH1, DNASE1, FEN1 COPS5 3600/4885ALDH1A1 2267/4885MAPT 706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.