Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 10/20 | 0.64 |
| ▸ | APEH | P13798 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616366 | 0.80 | PPME1 (0.60) | PPME1APEHL3MBTL1 | |
| SCHEMBL3964674 | 0.80 | PPME1 (0.58) | PPME1APEH | |
| SCHEMBL3968075 | 0.80 | PPME1 (0.55) | PPME1APEH | |
| SCHEMBL2457308 | 0.80 | RAPGEF4 (0.58) | PPME1APEHGAAL3MBTL1CA1 | |
| SCHEMBL3967048 | 0.76 | PPME1 (0.43) | PPME1APEH | |
| SCHEMBL3964676 | 0.76 | PPME1 (0.45) | PPME1APEH | |
| SCHEMBL3969097 | 0.72 | NOD1 (0.43) | PPME1APEH | |
| SCHEMBL3966831 | 0.70 | MET (0.49) | PPME1MAPT | |
| SCHEMBL9588098 | 0.70 | HTR6 (0.69) | PPME1L3MBTL1MAPT | |
| SCHEMBL1156699 | 0.69 | PAX8 (0.41) | PPME1GAAL3MBTL1CTSGCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |