SCHEMBL10033011

SCHEMBL10033011

CCOC(C(=O)O)c1cccc(NC(C)=O)c1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.52
▸ KMT2A Q03164 2/20 0.52
▸ RAB9A P51151 3/20 0.51
▸ POLB P06746 2/20 0.51
▸ NR4A1 P22736 1/20 0.51
▸ HSD17B10 Q99714 4/20 0.48
▸ TSHR P16473 1/20 0.48
▸ ALDH1A1 P00352 2/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ MAPT P10636 4/20 0.47
▸ NAPRT Q6XQN6 1/20 0.46
▸ NPC1 O15118 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ RORC P51449 3/20 0.46
▸ LMNA P02545 1/20 0.46
▸ MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1094337 0.82 KMT2A (0.54) MEN1KMT2ARAB9APOLBHSD17B10
SCHEMBL16589375 0.79 FFAR1 (0.45) ALDH1A1
SCHEMBL2553482 0.78 PPARA (0.49) POLBALDH1A1CYP1A2LMNAMAPK1
SCHEMBL6504745 0.78 PPARA (0.49) POLBALDH1A1CYP1A2LMNAMAPK1
SCHEMBL17653645 0.78 PPARA (0.49) POLBALDH1A1CYP1A2LMNAMAPK1
SCHEMBL3236680 0.78 FFAR1 (0.46) MEN1KMT2ALMNA
SCHEMBL758770 0.78 CPN1 (0.53) POLBALDH1A1SMN1; SMN2LMNA
SCHEMBL4854892 0.77 ALDH1A1 (0.55) MEN1KMT2ARAB9APOLBNR4A1
SCHEMBL13260957 0.77 HSD17B10 (0.58) MEN1KMT2ARAB9APOLBNR4A1
SCHEMBL10033007 0.77 PPARA (0.55) MEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11753365-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2023-09-12 — — US disclosed
US-11753365-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2023-09-12 — — US disclosed
US-20220354809-A1 Alkylamido Compounds and Uses Thereof NOGRA PHARMA LIMITED (IE) 2022-11-10 — — US disclosed
US-20220033346-A1 METHODS OF TREATING FIBROSIS NOGRA PHARMA LIMITED (IE) 2022-02-03 — — US disclosed
US-11046641-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2021-06-29 — — US disclosed
US-20210113505-A1 METHODS OF TREATING HAIR RELATED CONDITIONS NOGRA PHARMA LTD (IE) 2021-04-22 — — US disclosed
US-10959970-B2 Methods of treating hair related conditions NOGRA PHARMA LIMITED (IE) 2021-03-30 — — US disclosed
US-20200383942-A1 Alkylamido Compounds and Uses Thereof NOGRA PHARMA LIMITED (IE) 2020-12-10 — — US disclosed
US-20200188340-A1 Methods of Treating Hair Related Conditions GIULIANI INTERNATIONAL, LTD. (IE) 2020-06-18 — — US disclosed
US-20190269637-A1 Alkylamido Compounds and Uses Thereof GIULIANI INTERNATIONAL, LTD. (IE) 2019-09-05 — — US disclosed
US-20150087708-A1 METHODS OF TREATING FIBROSIS NOGRA PHARMA LIMITED (IE) 2015-03-26 — — US disclosed
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LIMITED (IE) 2015-03-26 — — US disclosed
US-20150051285-A1 Alkylamido Compounds and Uses Thereof NOGRA PHARMA LIMITED (IE) 2015-02-19 — — US disclosed
US-20150051285-A1 Alkylamido Compounds and Uses Thereof NOGRA PHARMA LIMITED (IE) 2015-02-19 — — US disclosed
US-8796334-B2 Methods of treating hair related conditions NOGRA PHARMA LIMITED (IE) 2014-08-05 — — US disclosed
US-8796334-B2 Methods of treating hair related conditions NOGRA PHARMA LIMITED (IE) 2014-08-05 — — US disclosed
US-8754127-B2 Alkylamido compounds and uses thereof NOGRA PHARMA LIMITED (IE) 2014-06-17 — — US disclosed
US-8754127-B2 Alkylamido compounds and uses thereof NOGRA PHARMA LIMITED (IE) 2014-06-17 — — US disclosed
US-20120053245-A1 Methods of Treating Hair Related Conditions GIULIANI INTERNATIONAL, LTD. (IE) 2012-03-01 — — US disclosed
US-20120053244-A1 Alkylamido Compounds and Uses Thereof NOGRA PHARMA LIMITED (IE) 2012-03-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220354809-A1 Alkylamido Compounds and Uses Thereof EGFR, PPARG, ERBB3 MEN1 4515/4885KMT2A 4005/4885RAB9A 2065/4885
US-20190269637-A1 Alkylamido Compounds and Uses Thereof EGFR, PPARG, ERBB3 MEN1 4515/4885KMT2A 4005/4885RAB9A 2065/4885
US-20200383942-A1 Alkylamido Compounds and Uses Thereof EGFR, PPARG, ERBB3 MEN1 4515/4885KMT2A 4005/4885RAB9A 2065/4885
US-20150087708-A1 METHODS OF TREATING FIBROSIS MMP1, MMP8, FABP2 MEN1 4490/4885KMT2A 3951/4885RAB9A 2827/4885
US-20150051285-A1 Alkylamido Compounds and Uses Thereof EGFR, PPARG, ERBB3 MEN1 4515/4885KMT2A 4005/4885RAB9A 2065/4885
US-11753365-B2 Methods of treating fibrosis MMP1, MMP8, FABP2 MEN1 4490/4885KMT2A 3951/4885RAB9A 2827/4885
US-20120053245-A1 Methods of Treating Hair Related Conditions PPARA, PPARG, PPARD MEN1 4764/4885KMT2A 2859/4885RAB9A 4459/4885
US-20210113505-A1 METHODS OF TREATING HAIR RELATED CONDITIONS EBP, AADAT, ALDH7A1 MEN1 4197/4885KMT2A 2183/4885RAB9A 4066/4885
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG MEN1 4879/4885KMT2A 3204/4885RAB9A 3521/4885
US-10959970-B2 Methods of treating hair related conditions PPARA, PPARG, PPARD MEN1 4764/4885KMT2A 2859/4885RAB9A 4459/4885
US-20200188340-A1 Methods of Treating Hair Related Conditions PPARA, PPARG, PPARD MEN1 4764/4885KMT2A 2859/4885RAB9A 4459/4885
US-20120053244-A1 Alkylamido Compounds and Uses Thereof EGFR, PPARG, ERBB3 MEN1 4515/4885KMT2A 4005/4885RAB9A 2065/4885
US-11046641-B2 Methods of treating fibrosis MMP1, MMP8, FABP2 MEN1 4490/4885KMT2A 3951/4885RAB9A 2827/4885
US-20220033346-A1 METHODS OF TREATING FIBROSIS MMP1, MMP8, FABP2 MEN1 4490/4885KMT2A 3951/4885RAB9A 2827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback