Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.72 |
| ▸ | MMP9 | P14780 | 4/20 | 0.71 |
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | TOP2A | P11388 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965107 | 0.87 | BACE1 (0.88) | BACE1MMP9MMP8AKR1B1MAOB | |
| SCHEMBL8965104 | 0.87 | BACE1 (0.88) | BACE1MMP9MMP8AKR1B1MAOB | |
| SCHEMBL3218771 | 0.84 | BACE1 (1.00) | BACE1MMP9AKR1B1MAOBAPP | |
| SCHEMBL3218761 | 0.84 | BACE1 (1.00) | BACE1MMP9AKR1B1MAOBAPP | |
| SCHEMBL10077707 | 0.83 | MMP9 (1.00) | BACE1MMP9MMP8AKR1B1MAOB | |
| SCHEMBL10077678 | 0.83 | MMP8 (0.71) | BACE1MMP9MMP8AKR1B1MAOB | |
| SCHEMBL14303722 | 0.78 | BACE1 (0.72) | BACE1MMP9AKR1B1MAOBAPP | |
| SCHEMBL12402527 | 0.78 | BACE1 (0.72) | BACE1MMP9MMP8AKR1B1MAOB | |
| SCHEMBL3216555 | 0.77 | APP (0.86) | BACE1MMP9MMP8AKR1B1MAOB | |
| SCHEMBL3216545 | 0.77 | APP (0.86) | BACE1MMP9MMP8AKR1B1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180036262-A1 | CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-02-08 | — | — | US | disclosed |
| US-20170158605-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2017-06-08 | — | — | US | disclosed |
| US-9556105-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160031795-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2016-02-04 | — | — | US | disclosed |
| US-9187406-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-03-12 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | ANTXR2, APAF1, LITAF | BACE1 1948/4885MMP9 1104/4885MMP8 248/4885 |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | BACE1 77/4885MMP9 12/4885MMP8 18/4885 |
| US-20170158605-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | BACE1 77/4885MMP9 12/4885MMP8 18/4885 |
| US-20160031795-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | BACE1 77/4885MMP9 12/4885MMP8 18/4885 |
| US-20180036262-A1 | CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS | ALOX15B, ALOX15, ALOX12 | BACE1 3470/4885MMP9 1330/4885MMP8 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.