SCHEMBL10105028

SCHEMBL10105028

Cc1cn(C)c(=S)[nH]c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
ALDH1A1 P00352 4/20 0.38
HPGD P15428 2/20 0.38
MAPT P10636 1/20 0.38
MAPK1 P28482 1/20 0.37
ATAD2 Q6PL18 1/20 0.35
TYMP P19971 1/20 0.35
TK1 P04183 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
DAO P14920 1/20 0.32
LMNA P02545 1/20 0.32
LPO P22079 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19888683 0.78 TDP1 (0.37) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL16248 0.77 MAPK1 (0.47) ALDH1A1HPGDMAPK1TYMPTK1
SCHEMBL18069601 0.77 ALDH1A1 (0.34) KMT2AMEN1ALDH1A1HPGDSMN1; SMN2
SCHEMBL16575964 0.77 LMNA (0.37) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL28313542 0.77 KMT2A (0.35) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL23482940 0.77 MAPK1 (0.36) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL28021080 0.77 TK1 (0.36) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL28216800 0.77 MAPK1 (0.40) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL6420314 0.76 MAPK1 (0.46) ALDH1A1HPGDMAPK1TYMPTK1
SCHEMBL24205178 0.74 MAPK1 (0.45) ALDH1A1HPGDMAPK1TYMPTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9875904-B2 Silicon etching liquid, silicon etching method, and microelectromechanical element MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2018-01-23 US claimed
US-20150340241-A1 SILICON ETCHING LIQUID, SILICON ETCHING METHOD, AND MICROELECTROMECHANICAL ELEMENT MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2015-11-26 US claimed
US-20210206809-A1 PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY VERA THERAPEUTICS INC (US) 2021-07-08 US disclosed
US-9875904-B2 Silicon etching liquid, silicon etching method, and microelectromechanical element MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2018-01-23 US disclosed
US-20170369872-A1 REVERSIR TM COMPOUNDS ALNYLAM PHARMACEUTICALS, INC. (US) 2017-12-28 US disclosed
US-9732110-B2 Nucleoside and nucleotide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2017-08-15 US disclosed
US-9675632-B2 Nucleoside and nucleotide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2017-06-13 US disclosed
US-20150340241-A1 SILICON ETCHING LIQUID, SILICON ETCHING METHOD, AND MICROELECTROMECHANICAL ELEMENT MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2015-11-26 US disclosed
US-8163707-B2 4′-allene-substituted nucleoside derivatives ENANTA PHARMACEUTICALS, INC. (US) 2012-04-24 US disclosed
US-20110257244-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND SMALL MOLECULES FOR USE IN REDUCING MICRO RNA ACTIVITY LEVELS AND USES THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2011-10-20 US disclosed
US-20110166198-A1 RNA COMPOSITIONS FOR MODULATING IMMUNE RESPONSE ALNYLAM PHARMACEUTICALS, INC. (US) 2011-07-07 US disclosed
US-20110065774-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF ALNYLAM PHARMACEUTICALS (US) 2011-03-17 US disclosed
US-7851155-B2 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation BOSTON PROBES, INC. (US) 2010-12-14 US disclosed
US-7745126-B2 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation BOSTON PROBES, INC. (US) 2010-06-29 US disclosed
US-20100074889-A1 4'-ALLENE-SUBSTITUTED NUCLEOSIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. 2010-03-25 US disclosed
US-7638279-B2 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation BOSTON PROBES, INC. (US) 2009-12-29 US disclosed
US-20090163381-A1 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation APPLERA CORPORATION. (US) 2009-06-25 US disclosed
US-20080269074-A1 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation APPLERA CORPORATION (US) 2008-10-30 US disclosed
US-20080206747-A1 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation APPLERA COPORATION (US) 2008-08-28 US disclosed
US-20080085837-A1 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation APPLERA CORPORATION (US) 2008-04-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110257244-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND SMALL MOLECULES FOR USE IN REDUCING MICRO RNA ACTIVITY LEVELS AND USES THEREOF AGO2, BCDIN3D, TRDMT1 KMT2A 847/4885MEN1 1178/4885ALDH1A1 2937/4885
US-20110065774-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF DCLRE1B, RNGTT, NSUN2 KMT2A 943/4885MEN1 3523/4885ALDH1A1 1270/4885
US-20100074889-A1 4'-ALLENE-SUBSTITUTED NUCLEOSIDE DERIVATIVES CCNI, CCNA1, CDK1 KMT2A 3869/4885MEN1 4441/4885ALDH1A1 770/4885
US-20110166198-A1 RNA COMPOSITIONS FOR MODULATING IMMUNE RESPONSE EIF2AK2, IRF3, NSUN2 KMT2A 1526/4885MEN1 3843/4885ALDH1A1 4606/4885
US-20210206809-A1 PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY AGO2, TARBP1, TPR KMT2A 1921/4885MEN1 2159/4885ALDH1A1 4394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.