Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21100162 | 0.90 | ALDH1A1 (0.50) | RAB9AALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL10636547 | 0.85 | PTGS2 (0.51) | RAB9AKMT2ANPC1ALDH1A1MEN1 | |
| SCHEMBL24934757 | 0.85 | RAB9A (0.48) | RAB9AKMT2AFKBP1ANPC1ALDH1A1 | |
| SCHEMBL24935661 | 0.84 | RAB9A (0.47) | RAB9AKMT2AFKBP1ANPC1ALDH1A1 | |
| SCHEMBL24935185 | 0.84 | KMT2A (0.50) | RAB9AKMT2AFKBP1ANPC1RXRA | |
| SCHEMBL17245028 | 0.83 | LMNA (0.53) | RAB9AKMT2AFKBP1ANPC1ALDH1A1 | |
| SCHEMBL8302859 | 0.83 | RAB9A (0.59) | RAB9AKMT2AFKBP1ANPC1ALDH1A1 | |
| SCHEMBL801233 | 0.83 | ALDH1A1 (0.72) | RAB9AKMT2AFKBP1ANPC1ALDH1A1 | |
| SCHEMBL25144590 | 0.81 | MAPT (0.47) | RAB9ANPC1ALDH1A1TSHRMAPT | |
| SCHEMBL6717854 | 0.81 | RAB9A (0.58) | RAB9AKMT2AFKBP1ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030911-B2 | Synthesis and biological activity of phosphoramidimidate and phosphoramidate DNA | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2024-07-09 | — | — | US | disclosed |
| US-20230054270-A1 | BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) | 2023-02-23 | — | — | US | disclosed |
| EP-4119546-A1 | BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Suzhou Kintor Pharmaceuticals, Inc. (CN) | 2023-01-18 | — | — | EP | disclosed |
| US-20220144867-A1 | SYNTHESIS OF BACKBONE MODIFIED MORPHOLINO OLIGONUCLEOTIDES AND CHIMERAS USING PHOSPHORAMIDITE CHEMISTRY | UNIV COLORADO REGENTS (US) | 2022-05-12 | — | — | US | disclosed |
| US-11230565-B2 | Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2022-01-25 | — | — | US | disclosed |
| US-10882884-B2 | Stereoselective synthesis of phosphorothioate oligoribonucleotides | ETH ZURICH (CH) | 2021-01-05 | — | — | US | disclosed |
| US-20190218236-A1 | SYNTHESIS OF BACKBONE MODIFIED MORPHOLINO OLIGONUCLEOTIDES AND CHIMERAS USING PHOSPHORAMIDITE CHEMISTRY | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2019-07-18 | — | — | US | disclosed |
| US-20190135849-A1 | STEREOSELECTIVE SYNTHESIS OF PHOSPHOROTHIOATE OLIGORIBONUCLEOTIDES | ETH ZURICH (CH) | 2019-05-09 | — | — | US | disclosed |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030911-B2 | Synthesis and biological activity of phosphoramidimidate and phosphoramidate DNA | RNASEH1, RNASE1, DNASE1 | RAB9A 3900/4885KMT2A 2433/4885FKBP1A 2259/4885 |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | RAB9A 1586/4885KMT2A 1703/4885FKBP1A 1275/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | RAB9A 1586/4885KMT2A 1703/4885FKBP1A 1275/4885 |
| US-11230565-B2 | Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry | RNASEH1, RNASE1, PMM2 | RAB9A 4314/4885KMT2A 996/4885FKBP1A 2977/4885 |
| US-20220144867-A1 | SYNTHESIS OF BACKBONE MODIFIED MORPHOLINO OLIGONUCLEOTIDES AND CHIMERAS USING PHOSPHORAMIDITE CHEMISTRY | RNASEH1, RNASE1, PMM2 | RAB9A 4314/4885KMT2A 996/4885FKBP1A 2977/4885 |
| US-20190218236-A1 | SYNTHESIS OF BACKBONE MODIFIED MORPHOLINO OLIGONUCLEOTIDES AND CHIMERAS USING PHOSPHORAMIDITE CHEMISTRY | RNASEH1, RNASE1, PMM2 | RAB9A 4314/4885KMT2A 996/4885FKBP1A 2977/4885 |
| US-20190135849-A1 | STEREOSELECTIVE SYNTHESIS OF PHOSPHOROTHIOATE OLIGORIBONUCLEOTIDES | RNGTT, TYMS, POLR2E | RAB9A 4069/4885KMT2A 4304/4885FKBP1A 572/4885 |
| US-10882884-B2 | Stereoselective synthesis of phosphorothioate oligoribonucleotides | RNGTT, TYMS, POLR2E | RAB9A 4069/4885KMT2A 4304/4885FKBP1A 572/4885 |
| US-20230054270-A1 | BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | AR, SHBG, NR5A1 | RAB9A 4121/4885KMT2A 1807/4885FKBP1A 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.