Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 6/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6226055 | 1.00 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL6226053 | 1.00 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL27019949 | 0.77 | POLB (0.41) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL30008978 | 0.77 | CRBN (0.38) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL6837311 | 0.75 | MAP1LC3B (0.47) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL955853 | 0.72 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL3142596 | 0.72 | SMN1; SMN2 (0.52) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL21635879 | 0.70 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL116223 | 0.67 | — | — | |
| SCHEMBL24852911 | 0.65 | MAP1LC3B (0.44) | MAPTSMN1; SMN2ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-12 | — | — | US | disclosed |
| US-20230002374-A1 | GPR52 MODULATOR COMPOUNDS | NXERA PHARMA UK LIMITED (GB) | 2023-01-05 | — | — | US | disclosed |
| US-20230002374-A1 | GPR52 MODULATOR COMPOUNDS | NXERA PHARMA UK LIMITED (GB) | 2023-01-05 | — | — | US | disclosed |
| EP-4055016-A1 | GPR52 MODULATOR COMPOUNDS | Heptares Therapeutics Limited (GB) | 2022-09-14 | — | — | EP | disclosed |
| CN-114650992-A | GPR52 modulator compounds | 赫普泰雅治疗有限公司 | 2022-06-21 | — | — | CN | disclosed |
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | LEAD DISCOVERY CENTER GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| US-10745401-B2 | Condensed lactam derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-04 | — | — | US | disclosed |
| WO-2020022237-A1 | FUSED RING LACTAM DERIVATIVES | 大日本住友製薬株式会社 | 2020-01-30 | — | — | WO | disclosed |
| WO-2020022237-A1 | FUSED RING LACTAM DERIVATIVES | 大日本住友製薬株式会社 | 2020-01-30 | — | — | WO | disclosed |
| US-9504251-B2 | Pesticidal compositions and related methods | DOW AGROSCIENCES LLC (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150327551-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | CORTEVA AGRISCIENCE LLC | 2015-11-19 | — | — | US | disclosed |
| WO-2015175719-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | DOW AGROSCIENCES LLC (US) | 2015-11-19 | — | — | WO | disclosed |
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002374-A1 | GPR52 MODULATOR COMPOUNDS | GPR52, GPR119, GPR4 | MAPT 3912/4885SMN1; SMN2 2536/4885ALDH1A1 1435/4885 |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | MAPT 38/4885SMN1; SMN2 280/4885ALDH1A1 858/4885 |
| US-20150327551-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | ACHE, MYH9, UNC119 | MAPT 4488/4885SMN1; SMN2 2192/4885ALDH1A1 1561/4885 |
| US-10745401-B2 | Condensed lactam derivative | PSEN1, GRIN1, HDAC1 | MAPT 38/4885SMN1; SMN2 280/4885ALDH1A1 858/4885 |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | MAPT 720/4885SMN1; SMN2 1775/4885ALDH1A1 973/4885 |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | MAPT 38/4885SMN1; SMN2 280/4885ALDH1A1 858/4885 |
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | CDK1, CDK2, CDK15 | MAPT 3370/4885SMN1; SMN2 4011/4885ALDH1A1 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.