Sugi Predict

Sugi Predict / Compounds / SCHEMBL1024910

SCHEMBL1024910

SCHEMBL1024910

O=[N+]([O-])c1ccc(C(F)(F)F)cc1O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR35 Q9HC97 1/20 0.56
▸ TTR P02766 1/20 0.54
▸ KCNMA1 Q12791 1/20 0.51
▸ ALDH1A1 P00352 5/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ HPGD P15428 1/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ HIF1A Q16665 1/20 0.50
▸ TXNRD1 Q16881 1/20 0.50
▸ TXNRD3 Q86VQ6 1/20 0.50
▸ TXNRD2 Q9NNW7 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ AKR1B1 P15121 1/20 0.49
▸ AKR1C4 P17516 1/20 0.49
▸ AKR1C3 P42330 1/20 0.49
▸ AKR1C2 P52895 1/20 0.49
▸ AKR1C1 Q04828 1/20 0.49
▸ MAPT P10636 3/20 0.48
▸ MEN1 O00255 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6823350 1.00 GPR35 (0.56) GPR35TTRKCNMA1ALDH1A1CYP3A4
SCHEMBL4594989 0.86 TTR (0.52) GPR35TTRKCNMA1ALDH1A1CYP3A4
SCHEMBL1026402 0.85 ALDH1A1 (0.56) GPR35TTRKCNMA1ALDH1A1CYP3A4
SCHEMBL11271221 0.82 TTR (0.50) GPR35TTRKCNMA1ALDH1A1CYP3A4
SCHEMBL29878635 0.82 GPR35 (0.46) GPR35TTRKCNMA1AKR1B1AKR1C4
SCHEMBL7240751 0.82 ALDH1A1 (0.60) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL29942185 0.82 ALDH1A1 (0.60) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL31363714 0.81 GPR35 (0.56) GPR35ALDH1A1CYP3A4HPGDALOX15
SCHEMBL1027772 0.81 GPR35 (0.56) GPR35ALDH1A1CYP3A4HPGDALOX15
SCHEMBL11468627 0.81 MAPK1 (0.68) KCNMA1ALDH1A1AKR1B1AKR1C4AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240408093-A1 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. 2024-12-12 — — US disclosed
US-20240409533-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-12-12 — — US disclosed
CN-113874074-B HMOX1 inducers 米托布里奇公司 2024-11-01 — — CN disclosed
US-12071433-B2 HMOX1 inducers Astellas Engineered Small Molecules US, Incorporated (US) 2024-08-27 — — US disclosed
US-20240158412-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF FAXIAN THERAPEUTICS, LLC 2024-05-16 — — US disclosed
US-20240051952-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-02-15 — — US disclosed
EP-4288442-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF Faxian Therapeutics, LLC (US) 2023-12-13 — — EP disclosed
WO-2022170198-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF FAXIAN THERAPEUTICS, LLC (US) 2022-08-11 — — WO disclosed
US-20220177460-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2022-06-09 — — US disclosed
EP-3952990-A1 HMOX1 INDUCERS Mitobridge, Inc. (US) 2022-02-16 — — EP disclosed
US-6005008-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1999-12-21 — — US disclosed
EP-0947500-A1 SULFONAMIDE AND CARBOXAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 — — EP disclosed
CN-1215990-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORP (US) 1999-05-05 — — CN disclosed
US-5886044-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1999-03-23 — — US disclosed
EP-0896531-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-02-17 — — EP disclosed
US-5780483-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1998-07-14 — — US disclosed
EP-0809492-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-12-03 — — EP disclosed
WO-1997029743-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-08-21 — — WO disclosed
WO-1996025157-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-08-22 — — WO disclosed
US-3984405-A PYRIDO(3,2-B)(1,4)OXAZIN-3(4H)-ONES E. R. SQUIBB & SONS, INC. (US) 1976-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158412-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF USP7, USP28, USP1 GPR35 4126/4885TTR 2607/4885KCNMA1 4543/4885
US-20240409533-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS GPR35 4365/4885TTR 1866/4885KCNMA1 4081/4885
US-20240408093-A1 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE FGFR3, FGFR1, ERBB3 GPR35 467/4885TTR 4513/4885KCNMA1 2787/4885
US-12071433-B2 HMOX1 inducers HMOX1, HMOX2, HMBS GPR35 4068/4885TTR 1727/4885KCNMA1 3721/4885
US-20240051952-A1 HMOX1 INDUCERS HMOX1, HMOX2, QSOX1 GPR35 3984/4885TTR 546/4885KCNMA1 3227/4885
US-20220177460-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS GPR35 4068/4885TTR 1727/4885KCNMA1 3721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.