Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027475 | 0.82 | NPC1 (0.44) | HSD17B10RECQLCHRM4KDM4ELMNA | |
| SCHEMBL1031744 | 0.80 | NPC1 (0.49) | ALDH1A1HSD17B10RECQLKDM4ELMNA | |
| SCHEMBL1031680 | 0.79 | HPGDS (0.48) | ALDH1A1TAS1R3TAS1R1TAS1R2PDE2A | |
| SCHEMBL1032244 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HSD17B10TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL1032220 | 0.74 | RAB9A (0.47) | ALDH1A1HSD17B10KDM4EHTTLMNA | |
| SCHEMBL22729721 | 0.69 | PDE2A (0.51) | ALDH1A1HSD17B10TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5969897 | 0.69 | TAS1R3 (0.64) | ALDH1A1HSD17B10TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6319067 | 0.69 | RECQL (0.51) | ALDH1A1HSD17B10TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL1031516 | 0.68 | LMNA (0.54) | ALDH1A1HSD17B10KDM4ETSHRHTT | |
| SCHEMBL929418 | 0.68 | ADORA2A (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968591-B2 | 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments | GRUENENTHAL GMBH (DE) | 2011-06-28 | — | — | US | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | GRUENENTHAL GMBH (DE) | 2009-05-28 | — | — | US | claimed |
| US-7968591-B2 | 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments | GRUENENTHAL GMBH (DE) | 2011-06-28 | — | — | US | disclosed |
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | GRUENENTHAL GMBH (DE) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | OPRL1, TPH1, OPRK1 | ALDH1A1 2168/4885HSD17B10 3763/4885TAS1R3 1688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.