Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 14/20 | 0.38 |
| ▸ | HTR1B | P28222 | 9/20 | 0.37 |
| ▸ | HTR1D | P28221 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16610221 | 0.89 | MTNR1B (0.38) | MTNR1BMTNR1ASLC6A4HTR1AHTR1B | |
| SCHEMBL18080758 | 0.80 | MTNR1B (0.39) | MTNR1BMTNR1AHTR1AHTR1BHTR1D | |
| SCHEMBL20476737 | 0.77 | MTNR1A (0.43) | MTNR1BMTNR1ASLC6A4HTR1AHTR1B | |
| SCHEMBL13962815 | 0.77 | SLC6A4 (0.66) | MTNR1BMTNR1ASLC6A4HTR1AHTR1B | |
| SCHEMBL1050599 | 0.75 | MTNR1A (0.43) | MTNR1BMTNR1ASLC6A4HTR1ACYP3A4 | |
| SCHEMBL8243663 | 0.74 | HTR6 (0.47) | SLC6A4HTR1A | |
| SCHEMBL91364 | 0.72 | HTR2A (0.63) | MTNR1BMTNR1ASLC6A4HTR1AHTR1B | |
| SCHEMBL20476417 | 0.72 | HTR1A (0.42) | SLC6A4HTR1AHTR1BHTR1DKDM4E | |
| SCHEMBL13962824 | 0.71 | SLC6A4 (0.66) | MTNR1BMTNR1ASLC6A4HTR1AHTR1B | |
| SCHEMBL1049675 | 0.71 | ADRB2 (0.37) | MTNR1BMTNR1AHTR1DKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868036-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-01-11 | — | — | US | disclosed |
| US-7851634-B2 | 5-amino 4-hydroxy-7-(1H-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension | NOVARTIS AG (CH) | 2010-12-14 | — | — | US | disclosed |
| US-20080280895-A1 | 5-Amino-4-Hydroxy-7-(1H-Indolmethyl)-8-Methylnonamide Derivatives as Renin Inhibitors for the Treatment of Hypertension | NOVARTIS AG (CH) | 2008-11-13 | — | — | US | disclosed |
| US-20080058320-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-03-06 | — | — | US | disclosed |
| CN-1934082-A | Organic compounds | SPEEDEL EXPERIMENTA AG (CH) | 2007-03-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280895-A1 | 5-Amino-4-Hydroxy-7-(1H-Indolmethyl)-8-Methylnonamide Derivatives as Renin Inhibitors for the Treatment of Hypertension | REN, AGTR1, AGTR2 | MTNR1B 150/4885MTNR1A 162/4885SLC6A4 2264/4885 |
| US-20080058320-A1 | Organic Compounds | REN, AGTR1, ADH1C | MTNR1B 691/4885MTNR1A 1026/4885SLC6A4 1119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.