Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY4 known ✓ | P51582 | 1/20 | 0.37 |
| ▸ | P2RY6 known ✓ | Q15077 | 1/20 | 0.37 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.35 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.34 |
| ▸ | DUSP5 | Q16690 | 4/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | PLEC | Q15149 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiron SCHEMBL29385574 | 0.88 | DUSP5 (0.65) | DUSP5PTPN1DUSP6APPSIRT1 | |
| Tiron SCHEMBL22220 | 0.88 | DUSP5 (0.65) | DUSP5PTPN1DUSP6APPSIRT1 | |
| SCHEMBL5310574 | 0.88 | DUSP5 (0.65) | DUSP5PTPN1DUSP6APPSIRT1 | |
| Water SCHEMBL3205313 | 0.86 | DUSP5 (0.62) | DUSP5PTPN1DUSP6APPSIRT1 | |
| SCHEMBL10722008 | 0.86 | DUSP5 (0.62) | DUSP5PTPN1DUSP6APPSIRT1 | |
| Water SCHEMBL5097417 | 0.86 | DUSP5 (0.62) | DUSP5PTPN1DUSP6APPSIRT1 | |
| Ammonia Solution, Strong SCHEMBL9751555 | 0.86 | DUSP5 (0.62) | DUSP5PTPN1DUSP6APPSIRT1 | |
| Water SCHEMBL29379961 | 0.86 | DUSP5 (0.62) | DUSP5PTPN1DUSP6APPSIRT1 | |
| SCHEMBL31393 | 0.84 | DUSP5 (0.59) | DUSP5PTPN1DUSP6APPSIRT1 | |
| Potassium Ion SCHEMBL3222667 | 0.84 | DUSP5 (0.59) | DUSP5PTPN1DUSP6APPSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855218-A | Method for processing silver halide photographic lightsensitive materials | FUJI PHOTO FILM CO., LTD. (JP) | 1989-08-08 | — | — | US | disclosed |