Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038602 | 0.82 | PTGES (0.36) | PTGES | |
| SCHEMBL11615205 | 0.81 | PTGES (0.48) | PTGES | |
| SCHEMBL11616582 | 0.77 | PTGES (0.41) | PTGES | |
| SCHEMBL11617739 | 0.75 | PTGES (0.39) | PTGES | |
| SCHEMBL10755951 | 0.74 | — | — | |
| SCHEMBL11617589 | 0.73 | PTGES (0.40) | PTGES | |
| SCHEMBL11502604 | 0.73 | GMNN (0.32) | — | |
| SCHEMBL11502974 | 0.73 | GHSR (0.32) | PTGES | |
| SCHEMBL11035846 | 0.72 | GHSR (0.34) | PTGES | |
| SCHEMBL11615496 | 0.72 | GHSR (0.40) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4729990-A | PENICILLIN | FARMITALIA CARLO ERBA S.P.A. (IT) | 1988-03-08 | — | — | US | disclosed |
| US-4577016-A | DISPLACEMENT | FARMITALIA CARLO ERBA S.P.A. (IT) | 1986-03-18 | — | — | US | disclosed |
| EP-0043713-B1 | ANTIBACTERIAL CEPHALOSPORINS | SMITHKLINE BECKMAN CORPORATION (US) | 1984-09-26 | — | — | EP | disclosed |
| EP-0043713-A1 | Antibacterial cephalosporins | SMITHKLINE BECKMAN CORPORATION (US) | 1982-01-13 | — | — | EP | disclosed |
| US-4308267-A | 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins | SMITHKLINE CORPORATION (US) | 1981-12-29 | — | — | US | disclosed |
| US-4178288-A | Sulfaminoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins | SMITHKLINE CORPORATION (US) | 1979-12-11 | — | — | US | disclosed |
| US-4171362-A | 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4171433-A | 7-Amino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporin intermediates for preparing 7-acylamino cephalosporins | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4171368-A | 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4118491-A | 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1978-10-03 | — | — | US | disclosed |
| US-4066762-A | ANTIBACTERIAL | SMITHKLINE CORPORATION (US) | 1978-01-03 | — | — | US | disclosed |