Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693819 | 0.86 | OPRD1 (0.40) | EHMT2RAD52 | |
| SCHEMBL10691593 | 0.85 | L3MBTL1 (0.42) | PKMMAPTALDH1A1LMNATSHR | |
| SCHEMBL10695401 | 0.82 | RAD52 (0.42) | PKMEHMT2RAD52MAPTKDM4E | |
| SCHEMBL10692789 | 0.78 | BACE1 (0.37) | EHMT2MAPTALDH1A1SLC6A2LMNA | |
| SCHEMBL10691597 | 0.74 | ADRA1A (0.39) | RAD52MAPTALDH1A1HPGDTSHR | |
| SCHEMBL10692622 | 0.73 | CNR1 (0.39) | GPR55CNR1PKMEHMT2SLC6A2 | |
| SCHEMBL10693674 | 0.71 | BACE1 (0.35) | ALDH1A1LMNAHTTTSHRHSD17B10 | |
| SCHEMBL2470209 | 0.69 | NOTUM (0.46) | EHMT2RAD52MAPTKDM4EKDM4C | |
| SCHEMBL10694665 | 0.69 | RAD52 (0.36) | PKMEHMT2RAD52MAPTKDM4E | |
| SCHEMBL10696619 | 0.67 | RAD52 (0.34) | PKMEHMT2RAD52MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |