Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | DBH | P09172 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | ABAT | P80404 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18769014 | 0.85 | RAB9A (0.55) | HDAC3HDAC6NCOR2SMN1; SMN2TPSAB1 | |
| SCHEMBL480603 | 0.83 | KMT2A (0.58) | HDAC6KDM4EDBHGAARECQL | |
| SCHEMBL3685675 | 0.83 | KDM4E (0.50) | KDM4EDBHGAARECQLSMN1; SMN2 | |
| SCHEMBL10820400 | 0.82 | LOXL2 (0.50) | LOXL2HDAC3HDAC6NCOR2KDM4E | |
| SCHEMBL10121174 | 0.82 | KDM4E (0.62) | HDAC3HDAC6KDM4EDBHGAA | |
| SCHEMBL22668308 | 0.81 | LOXL2 (0.60) | LOXL2KDM4EDBHGAARECQL | |
| SCHEMBL28043314 | 0.81 | KMT2A (0.53) | LOXL2HDAC3HDAC6NCOR2KDM4E | |
| SCHEMBL12158530 | 0.81 | SLC6A2 (0.49) | KDM4EDBHGAARECQLSMN1; SMN2 | |
| SCHEMBL3129690 | 0.81 | ALDH1A1 (0.59) | KDM4EDBHGAARECQLSMN1; SMN2 | |
| SCHEMBL22249514 | 0.79 | CA1 (0.55) | HDAC6KDM4EDBHGAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662177-B2 | Blocking toll-like receptor 9 signaling with small molecule antagonist | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-05-26 | — | — | US | disclosed |
| US-20190276489-A1 | PROGESTERONE ANALOGS AND USES RELATED THERETO | EMORY UNIVERSITY | 2019-09-12 | — | — | US | disclosed |
| US-10336787-B2 | Progesterone analogs and uses related thereto | EMORY UNIVERSITY (US) | 2019-07-02 | — | — | US | disclosed |
| US-20190092758-A1 | BLOCKING TOLL-LIKE RECEPTOR 9 SIGNALING WITH SMALL MOLECULE ANTAGONIST | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2019-03-28 | — | — | US | disclosed |
| US-20130210785-A1 | PROGESTERONE ANALOGS AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-15 | — | — | US | disclosed |
| US-8222381-B2 | Derivatives of monosaccharides for drug discovery | ALCHEMIA LIMITED (AU) | 2012-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336787-B2 | Progesterone analogs and uses related thereto | PGR, SHBG, PGRMC1 | LOXL2 569/4885HDAC3 1583/4885HDAC6 1978/4885 |
| US-20190092758-A1 | BLOCKING TOLL-LIKE RECEPTOR 9 SIGNALING WITH SMALL MOLECULE ANTAGONIST | TLR9, TLR1, TLR3 | LOXL2 2956/4885HDAC3 940/4885HDAC6 666/4885 |
| US-10662177-B2 | Blocking toll-like receptor 9 signaling with small molecule antagonist | TLR9, TLR1, TLR3 | LOXL2 2750/4885HDAC3 795/4885HDAC6 517/4885 |
| US-20130210785-A1 | PROGESTERONE ANALOGS AND USES RELATED THERETO | PGR, SHBG, PGRMC1 | LOXL2 569/4885HDAC3 1583/4885HDAC6 1978/4885 |
| US-20190276489-A1 | PROGESTERONE ANALOGS AND USES RELATED THERETO | PGR, SHBG, PGRMC1 | LOXL2 569/4885HDAC3 1583/4885HDAC6 1978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.