Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194501 | 0.88 | LMNA (0.51) | GAADRD4TSHRHTTLMNA | |
| SCHEMBL10851723 | 0.87 | TNKS (0.50) | GAATSHRHTTALDH1A1KDM4E | |
| SCHEMBL11200656 | 0.87 | SIGMAR1 (0.57) | GAASIGMAR1DRD4TSHRHTT | |
| SCHEMBL11197047 | 0.86 | KDM4E (0.52) | GAADRD4KDM4EMAPK1MAPT | |
| SCHEMBL11205135 | 0.86 | HTR1A (0.55) | SIGMAR1DRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL11196110 | 0.86 | ALDH1A1 (0.50) | GAATSHRHTTLMNAALDH1A1 | |
| SCHEMBL11206897 | 0.84 | ALDH1A1 (0.54) | TSHRHTTLMNAALDH1A1KDM4E | |
| SCHEMBL11203954 | 0.83 | SIGMAR1 (0.58) | SIGMAR1POLB | |
| SCHEMBL10860653 | 0.82 | SIGMAR1 (0.54) | GAASIGMAR1TSHRHTTLMNA | |
| SCHEMBL11201299 | 0.82 | USP2 (0.50) | GAATSHRALDH1A1USP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4421753-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1983-12-20 | — | — | US | claimed |
| US-4582833-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-04-15 | — | — | US | disclosed |