Sugi Predict

Sugi Predict / Compounds / SCHEMBL11031397

SCHEMBL11031397

SCHEMBL11031397

COC(=O)C(C(C)=O)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.62
▸ MMP8 P22894 1/20 0.53
▸ ALDH1A1 P00352 4/20 0.50
▸ SRC P12931 1/20 0.50
▸ MEN1 O00255 2/20 0.46
▸ PTGS1 P23219 1/20 0.46
▸ PTGS2 P35354 1/20 0.46
▸ LMNA P02545 1/20 0.46
▸ GLS O94925 2/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ TSHR P16473 2/20 0.43
▸ HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3598733 0.90 KMT2A (0.69) KMT2AMMP8ALDH1A1SRCMEN1
Ammonia Solution, Strong SCHEMBL27830689 0.88 KMT2A (0.67) KMT2AMMP8ALDH1A1SRCMEN1
SCHEMBL2914808 0.86 KMT2A (0.64) KMT2AMMP8ALDH1A1SRCMEN1
SCHEMBL583575 0.85 MMP8 (0.68) KMT2AMMP8SRCMEN1TSHR
SCHEMBL6959628 0.84 KMT2A (0.62) KMT2AMMP8ALDH1A1SRCMEN1
SCHEMBL2227571 0.84 KMT2A (0.62) KMT2AMMP8ALDH1A1SRCMEN1
SCHEMBL28365013 0.83 MMP8 (0.66) KMT2AMMP8SRCMEN1TSHR
SCHEMBL1312762 0.83 SRC (0.64) KMT2AMMP8ALDH1A1SRCLMNA
SCHEMBL29287592 0.82 SRC (0.48) KMT2AMMP8ALDH1A1SRCMEN1
SCHEMBL18650052 0.82 SRC (0.48) KMT2AMMP8ALDH1A1SRCMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226094-A1 ALPHA PROTEIN KINASE 1 INHIBITORS FOR USE IN TREATING KAWASAKI DISEASE XU, Cong (CN) 2024-07-11 — — US disclosed
US-20240226094-A1 ALPHA PROTEIN KINASE 1 INHIBITORS FOR USE IN TREATING KAWASAKI DISEASE XU, Cong (CN) 2024-07-11 — — US disclosed
US-RE49934-E1 Inhibitors of cellular metabolic processes SERVIER PHARMACEUTICALS LLC (US) 2024-04-23 — — US disclosed
CN-109890822-B Inhibitors of cellular metabolic processes 安吉奥斯医药品有限公司 2022-08-30 — — CN disclosed
US-11325914-B1 Inhibitors of cellular metabolic processes SERVIER PHARMACEUTICALS LLC (US) 2022-05-10 — — US disclosed
US-11325914-B1 Inhibitors of cellular metabolic processes SERVIER PHARMACEUTICALS LLC (US) 2022-05-10 — — US disclosed
US-10800782-B2 Inhibitors of cellular metabolic processes Agios Pharmaceutical, Inc. (US) 2020-10-13 — — US disclosed
US-10800782-B2 Inhibitors of cellular metabolic processes Agios Pharmaceutical, Inc. (US) 2020-10-13 — — US disclosed
US-20190233424-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES SERVIER PHARMACEUTICALS LLC 2019-08-01 — — US disclosed
US-20190233424-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES SERVIER PHARMACEUTICALS LLC 2019-08-01 — — US disclosed
US-20180079753-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES SERVIER PHARMACEUTICALS LLC 2018-03-22 — — US disclosed
US-20180079753-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES SERVIER PHARMACEUTICALS LLC 2018-03-22 — — US disclosed
WO-2018045071-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES AGIOS PHARMACEUTICALS, INC. (US) 2018-03-08 — — WO disclosed
US-9682938-B2 Pyrazolone derivatives as nitroxyl donors CARDIOXYL PHARMACEUTICALS, INC. (US) 2017-06-20 — — US disclosed
EP-3148972-A1 PYRAZOLONE DERIVATIVES AS NITROXYL DONORS Cardioxyl Pharmaceuticals Inc. (US) 2017-04-05 — — EP disclosed
WO-2015183839-A1 PYRAZOLONE DERIVATIVES AS NITROXYL DONORS CARDIOXYL PHARMACEUTICALS, INC. (US) 2015-12-03 — — WO disclosed
US-20150344437-A1 PYRAZOLONE DERIVATIVES AS NITROXYL DONORS THE JOHNS HOPKINS UNIVERSITY 2015-12-03 — — US disclosed
US-20130150613-A1 SYNTHESIS OF HALF ESTERS TIMES THREE WIRELESS, INC. (CA) 2013-06-13 — — US disclosed
US-4515915-A Polyamide acid composition for preparing polyimide KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1985-05-07 — — US disclosed
EP-0114059-A2 Method of preparing a polyamide acid composition for preparing polyimide KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1984-07-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240226094-A1 ALPHA PROTEIN KINASE 1 INHIBITORS FOR USE IN TREATING KAWASAKI DISEASE PHKA1, PHKA2, PHKG1 KMT2A 3181/4885MMP8 1812/4885ALDH1A1 3290/4885
US-20150344437-A1 PYRAZOLONE DERIVATIVES AS NITROXYL DONORS TNNI3, PFKP, NOX5 KMT2A 4665/4885MMP8 667/4885ALDH1A1 1883/4885
US-20190233424-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES MNAT1, MAT2A, PCK2 KMT2A 734/4885MMP8 3942/4885ALDH1A1 352/4885
US-20130150613-A1 SYNTHESIS OF HALF ESTERS BCKDK, CES1, KHK KMT2A 1315/4885MMP8 1423/4885ALDH1A1 1455/4885
US-10800782-B2 Inhibitors of cellular metabolic processes MNAT1, MAT2A, PCK2 KMT2A 734/4885MMP8 3942/4885ALDH1A1 352/4885
US-20180079753-A1 INHIBITORS OF CELLULAR METABOLIC PROCESSES MNAT1, MAT2A, PCK2 KMT2A 734/4885MMP8 3942/4885ALDH1A1 352/4885
US-11325914-B1 Inhibitors of cellular metabolic processes MNAT1, MAT2A, PCK2 KMT2A 734/4885MMP8 3942/4885ALDH1A1 352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.