Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089344 | 0.81 | NR3C1 (0.42) | PTGS2BRD4HSD17B2NR1H2NR1H3 | |
| SCHEMBL5032009 | 0.67 | CRHBP (0.41) | PTGS2BRD4CRHBPCRHR2LMNA | |
| SCHEMBL1642859 | 0.66 | ADRA2C (0.33) | MEN1KMT2A | |
| SCHEMBL16001320 | 0.65 | ALDH1A1 (0.40) | BRD4NR1H2NR1H3KMT2A | |
| SCHEMBL11091627 | 0.64 | CFTR (0.37) | PTGS2BRD4LMNAMEN1TSHR | |
| SCHEMBL31678621 | 0.64 | ACHE (0.40) | PTGS2BRD4CRHBPCRHR2LMNA | |
| SCHEMBL8759879 | 0.63 | CES2 (0.41) | BRD4LMNAMEN1KMT2A | |
| SCHEMBL7678480 | 0.63 | CES2 (0.41) | BRD4LMNAMEN1KMT2A | |
| SCHEMBL22792110 | 0.63 | GPR3 (0.60) | LMNAMEN1KMT2A | |
| SCHEMBL19508807 | 0.63 | CASP3 (0.45) | LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443616-A | Production of 3-pyrrolin-2-ones | THE PURDUE FREDERICK COMPANY (US) | 1984-04-17 | — | — | US | disclosed |