Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 5/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.40 |
| ▸ | STAT1 | P42224 | 2/20 | 0.40 |
| ▸ | STAT5A | P42229 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | STAT5B | P51692 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11590490 | 0.89 | APEX1 (0.65) | APEX1PTPN1P2RY11SIRT1PRMT1 | |
| SCHEMBL11588299 | 0.87 | P2RY11 (0.54) | APEX1PTPN1P2RY11FGF1SIRT1 | |
| SCHEMBL11589914 | 0.85 | APEX1 (0.59) | APEX1PTPN1FGF1SIRT1PRMT1 | |
| SCHEMBL11589832 | 0.80 | PTPN1 (0.47) | APEX1PTPN1P2RY11SIRT1PRMT1 | |
| SCHEMBL9411862 | 0.80 | APEX1 (0.77) | APEX1PTPN1FGF1SIRT1PRMT1 | |
| SCHEMBL11136921 | 0.80 | APEX1 (0.65) | APEX1PTPN1P2RY11SIRT1PRMT1 | |
| SCHEMBL11435700 | 0.80 | APEX1 (0.56) | APEX1PTPN1P2RY11FGF1SIRT1 | |
| SCHEMBL11440906 | 0.80 | APEX1 (0.56) | APEX1PTPN1P2RY11SIRT1PRMT1 | |
| SCHEMBL11513617 | 0.78 | APEX1 (0.50) | APEX1PTPN1P2RY11SIRT1PRMT1 | |
| SCHEMBL11427857 | 0.77 | CASP6 (0.44) | APEX1MAPTBLMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4391824-A | INHIBITING CONNECTIVE TISSUE DISTRUCTION, ENZYME INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1983-07-05 | — | — | US | disclosed |
| US-4127602-A | Methyl substituted hydroxynaphthalenesulfonic acid ureides and salts as complement inhibitors | AMERICAN CYANAMID COMPANY (US) | 1978-11-28 | — | — | US | disclosed |