Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 1/20 | 0.46 |
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.45 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.45 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 3/20 | 0.77 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10904449 | 0.90 | APEX1 (0.62) | APEX1PTPN1DUSP5FGF1PRMT1 | |
| SCHEMBL11589914 | 0.88 | APEX1 (0.59) | APEX1PTPN1DUSP5ENPP2FGF1 | |
| SCHEMBL9411865 | 0.87 | APEX1 (1.00) | APEX1ENPP2PRMT1CA12CA1 | |
| SCHEMBL8928454 | 0.87 | APEX1 (0.81) | APEX1ENPP2CA12CA1CA2 | |
| SCHEMBL1413131 | 0.87 | APEX1 (1.00) | APEX1ENPP2PRMT1CA12CA1 | |
| SCHEMBL1514687 | 0.86 | APEX1 (0.57) | APEX1DUSP5ENPP2FGF1PRMT1 | |
| SCHEMBL11588299 | 0.80 | P2RY11 (0.54) | APEX1PTPN1DUSP5FGF1PRMT1 | |
| SCHEMBL11139657 | 0.80 | APEX1 (0.51) | APEX1PTPN1DUSP5ENPP2FGF1 | |
| SCHEMBL11508852 | 0.80 | APEX1 (0.84) | APEX1ENPP2POLBKMT2AMEN1 | |
| SCHEMBL30118451 | 0.80 | PTPN1 (0.63) | APEX1PTPN1DUSP5PRMT1SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6228447-A | — | — | None | — | — | JP | disclosed |
| JP-H06228447-A | MAGENTA DYE, JET INK, AND COLOR SET | LEXMARK INTERNATL INC | 1994-08-16 | — | — | JP | disclosed |