Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 1/20 | 0.43 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.41 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.41 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.41 |
| ▸ | P2RY11 | Q96G91 | 4/20 | 0.54 |
| ▸ | APEX1 | P27695 | 6/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 5/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.46 |
| ▸ | RECQL | P46063 | 5/20 | 0.46 |
| ▸ | BLM | P54132 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | STAT1 | P42224 | 4/20 | 0.46 |
| ▸ | STAT5A | P42229 | 4/20 | 0.46 |
| ▸ | STAT5B | P51692 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11588309 | 0.89 | APEX1 (0.65) | P2RY11APEX1PTPN1LMNAPOLB | |
| SCHEMBL11139657 | 0.87 | APEX1 (0.51) | P2RY11APEX1PTPN1LMNAPOLB | |
| SCHEMBL11589914 | 0.81 | APEX1 (0.59) | APEX1PTPN1LMNAPOLBMAPT | |
| SCHEMBL9411862 | 0.80 | APEX1 (0.77) | APEX1PTPN1LMNAPOLBMAPT | |
| SCHEMBL11347946 | 0.80 | APEX1 (0.56) | P2RY11APEX1PTPN1POLBMAPT | |
| SCHEMBL11588071 | 0.80 | SIRT1 (0.56) | P2RY11APEX1PTPN1LMNAPOLB | |
| SCHEMBL11342310 | 0.80 | APEX1 (0.56) | P2RY11APEX1PTPN1MAPTPKM | |
| SCHEMBL11347176 | 0.77 | TIMP3 (0.45) | P2RY11APEX1PTPN1POLBMAPT | |
| SCHEMBL11589832 | 0.76 | PTPN1 (0.47) | P2RY11APEX1PTPN1LMNAPOLB | |
| SCHEMBL30118451 | 0.76 | PTPN1 (0.63) | APEX1PTPN1POLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127602-A | Methyl substituted hydroxynaphthalenesulfonic acid ureides and salts as complement inhibitors | AMERICAN CYANAMID COMPANY (US) | 1978-11-28 | — | — | US | claimed |
| US-4127602-A | Methyl substituted hydroxynaphthalenesulfonic acid ureides and salts as complement inhibitors | AMERICAN CYANAMID COMPANY (US) | 1978-11-28 | — | — | US | disclosed |