Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11496728 | 0.83 | ALDH1A1 (0.46) | ALDH1A1NPC1L3MBTL1GAASIGMAR1 | |
| SCHEMBL11490047 | 0.81 | SIGMAR1 (0.42) | ALDH1A1GAASIGMAR1HRH4HRH3 | |
| SCHEMBL14973632 | 0.75 | L3MBTL1 (0.51) | ALDH1A1L3MBTL1GAAMAPTPOLB | |
| SCHEMBL11259082 | 0.75 | ALDH1A1 (0.63) | ALDH1A1NPC1L3MBTL1SIGMAR1MAPT | |
| SCHEMBL8987611 | 0.75 | NPC1 (0.42) | ALDH1A1NPC1L3MBTL1PSEN1PSEN2 | |
| SCHEMBL11494201 | 0.74 | CNR2 (0.46) | ALDH1A1NPC1GAASIGMAR1POLB | |
| SCHEMBL8987641 | 0.72 | PYCR1 (0.51) | SIGMAR1POLB | |
| SCHEMBL11491368 | 0.71 | HPGD (0.49) | ALDH1A1NPC1GAASIGMAR1CYP1A2 | |
| SCHEMBL4879817 | 0.70 | ALDH1A1 (0.41) | ALDH1A1NPC1L3MBTL1GAAMAPT | |
| SCHEMBL11493896 | 0.70 | KMT2A (0.42) | ALDH1A1GAAMAPTPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4202832-A | ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-05-13 | — | — | US | disclosed |