Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 20/20 | 1.00 |
| ▸ | IMPDH1 | P20839 | 16/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | HPGD | P15428 | 1/20 | 0.82 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.82 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.81 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.81 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.81 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.81 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.81 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.81 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375645 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| SCHEMBL29463203 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| SCHEMBL24420499 | 0.93 | IMPDH2 (0.86) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| SCHEMBL18542936 | 0.92 | IMPDH2 (0.85) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| SCHEMBL18538602 | 0.92 | IMPDH2 (0.85) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| SCHEMBL13058820 | 0.91 | IMPDH2 (0.86) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| SCHEMBL14749220 | 0.91 | IMPDH2 (0.83) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL1657813 | 0.90 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL4549 | 0.90 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL5259872 | 0.90 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207411-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | SEAPORT THERAPEUTICS, INC. | 2024-06-27 | — | — | US | disclosed |
| EP-4306524-A2 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | PureTech LYT, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| US-20220211664-A1 | LYMPH DIRECTING PRODRUGS | MONASH UNIVERSITY (AU) | 2022-07-07 | — | — | US | disclosed |
| US-20220143038-A1 | LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF | PURETECH LYT, INC. (US) | 2022-05-12 | — | — | US | disclosed |
| US-20220001015-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | SEAPORT THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| CN-109305989-B | Phosphamide derivative and preparation method and application thereof | 四川海思科制药有限公司 | 2021-02-26 | — | — | CN | disclosed |
| US-20200390777-A1 | LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF | SEAPORT THERAPEUTICS, INC. | 2020-12-17 | — | — | US | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| US-10221152-B2 | Usage of mycophenolate mofetil or salt thereof in preparing drug for resisting against influenza virus | GIANT FORCE TECHNOLOGY CORPORATION (TW) | 2019-03-05 | — | — | US | disclosed |
| CN-109305989-A | A kind of phosphinylidyne amine derivative and preparation method and purposes | 四川海思科制药有限公司 | 2019-02-05 | — | — | CN | disclosed |
| US-20080085542-A1 | Using candida lipase to convert mycophenolic acid (MPA), ethanol and N-(2-hydroxyethyl)morpholine into mycophenolate mofetil | POLI INDUSTRIA CHIMICA SPA (IT) | 2008-04-10 | — | — | US | disclosed |
| EP-1105730-B1 | ENZYME INHIBITION IMMUNOASSAY | ROCHE DIAGNOSTICS OPERATIONS (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7235675-B2 | Conjugates of mycophenolic acid | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-20060199788-A1 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. | 2006-09-07 | — | — | US | disclosed |
| US-20060079478-A1 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. | 2006-04-13 | — | — | US | disclosed |
| US-20060035866-A1 | Phosphonate compounds having immuno-modulatory activity | GILEAD SCIENCES, INC. | 2006-02-16 | — | — | US | disclosed |
| US-20050256078-A1 | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds | GILEAD SCIENCES, INC. | 2005-11-17 | — | — | US | disclosed |
| US-20050215513-A1 | Use of an antiviral compound linked to one or more phosphonate groups in hepatitis C treatment; improved bioavailability, side effect reduction; antiviral compound is a 2-(2-isopropylaminothiazol-4-yl)-4-(tricyclic fused ring)-7-methoxy-quinoline compound | GILEAD SCIENCES, INC. | 2005-09-29 | — | — | US | disclosed |
| US-4959387-A | ISOBENZOFURAN COMPOUNDS | SYNTEX (U.S.A.) INC. (US) | 1990-09-25 | — | — | US | disclosed |
| US-4725622-A | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis | SYNTEX (U.S.A.) INC. (US) | 1988-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220001015-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | LIPA, MALT1, SGMS1 | IMPDH2 919/4885IMPDH1 890/4885KDM4E 2135/4885 |
| US-20060035866-A1 | Phosphonate compounds having immuno-modulatory activity | PHOSPHO1, NFATC1, IFNG | IMPDH2 464/4885IMPDH1 421/4885KDM4E 3404/4885 |
| US-10221152-B2 | Usage of mycophenolate mofetil or salt thereof in preparing drug for resisting against influenza virus | DUSP5, DUSP4, DUSP15 | IMPDH2 141/4885IMPDH1 103/4885KDM4E 250/4885 |
| US-20220211664-A1 | LYMPH DIRECTING PRODRUGS | LTA, ABCB11, LYN | IMPDH2 1172/4885IMPDH1 1220/4885KDM4E 3054/4885 |
| US-20200390777-A1 | LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF | MALT1, CYP2B6, LIPA | IMPDH2 462/4885IMPDH1 454/4885KDM4E 1491/4885 |
| US-20050215513-A1 | Use of an antiviral compound linked to one or more phosphonate groups in hepatitis C treatment; improved bioavailability, side effect reduction; antiviral compound is a 2-(2-isopropylaminothiazol-4-yl)-4-(tricyclic fused ring)-7-methoxy-quinoline compound | EIF2AK2, PNP, NUDT1 | IMPDH2 306/4885IMPDH1 239/4885KDM4E 2597/4885 |
| US-20060079478-A1 | Anti-cancer phosphonate analogs | PIK3CA, PHOSPHO1, PTEN | IMPDH2 1980/4885IMPDH1 1660/4885KDM4E 1893/4885 |
| US-20050256078-A1 | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds | IMPDH1, IMPDH2, ITPA | IMPDH2 2/4885IMPDH1 1/4885KDM4E 3149/4885 |
| US-20060199788-A1 | Anti-inflammatory phosphonate compounds | PHOSPHO1, TNF, PTGES | IMPDH2 2628/4885IMPDH1 2648/4885KDM4E 4225/4885 |
| US-20220143038-A1 | LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF | MALT1, CYP2B6, LIPA | IMPDH2 462/4885IMPDH1 454/4885KDM4E 1491/4885 |
| US-20240207411-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | LIPA, MALT1, SGMS1 | IMPDH2 919/4885IMPDH1 890/4885KDM4E 2135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.