Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11553593 | 0.81 | ALDH1A1 (0.45) | MIFMAOBMAOACYP19A1KDM4E | |
| SCHEMBL11550765 | 0.78 | TP53 (0.37) | MAOBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11548968 | 0.78 | MAPT (0.47) | MAOBMAOAKDM4EALDH1A1MAPT | |
| SCHEMBL11548529 | 0.77 | TP53 (0.36) | MAOBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL10743625 | 0.76 | FTO (0.35) | MAOBMAOAPTPN1CYP19A1KDM4E | |
| SCHEMBL12892170 | 0.76 | CYP11B1 (0.58) | MAOBMAOAPTPN1CYP11B1CYP11B2 | |
| SCHEMBL11503586 | 0.76 | ALOX15 (0.34) | MIFMAOBMAOACYP19A1KDM4E | |
| SCHEMBL11613988 | 0.75 | ALDH1A1 (0.44) | MAOAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8788013 | 0.73 | NISCH (0.50) | NISCHMIFMAOBMAOAPTPN1 | |
| SCHEMBL11552553 | 0.72 | MAOB (0.58) | MAOBMAOAPTPN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590142-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-03-17 | — | — | US | disclosed |
| EP-2991647-B1 | DEUTERATED AMLEXANOX WITH IMPROVED METABOLIC STABILITY | UNIV MICHIGAN REGENTS (US) | 2019-04-24 | — | — | EP | disclosed |
| US-9944652-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160251366-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2016-09-01 | — | — | US | disclosed |
| US-9365581-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2991647-A1 | DEUTERATED AMLEXANOX | The Regents Of The University Of Michigan (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20160060271-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-03-03 | — | — | US | disclosed |
| US-8946424-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-02-03 | — | — | US | disclosed |
| WO-2014179734-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-06 | — | — | WO | disclosed |
| US-20140329848-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-06 | — | — | US | disclosed |
| US-4151180-A | INTERMEDIATES FOR ANTIALLERGENS, ANTIHISTAMINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1979-04-24 | — | — | US | disclosed |
| US-4116971-A | 3-(1H-TETRAZOL-5-YL)CHROMONES | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590142-B2 | Deuterated amlexanox | DDX3X, DHX30, HAX1 | NISCH 1512/4885MIF 4686/4885MAOB 4481/4885 |
| US-20140329848-A1 | DEUTERATED AMLEXANOX | DDX3X, DHX30, HAX1 | NISCH 1512/4885MIF 4686/4885MAOB 4481/4885 |
| US-20160060271-A1 | DEUTERATED AMLEXANOX | AADAC, GPR119, IAPP | NISCH 1094/4885MIF 40/4885MAOB 3072/4885 |
| US-20160251366-A1 | DEUTERATED AMLEXANOX | DDX3X, DHX30, HAX1 | NISCH 1512/4885MIF 4686/4885MAOB 4481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.