Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11557327 | 0.86 | MAPT (0.56) | POLBNR4A2RAB9ALMNAALDH1A1 | |
| SCHEMBL11559300 | 0.78 | RORC (0.43) | POLBLMNAALDH1A1KMT2ANPSR1 | |
| SCHEMBL11553624 | 0.77 | CYP2C19 (0.53) | POLBLMNAMAPTHTTGSTO1 | |
| SCHEMBL11554622 | 0.77 | GSTO1 (0.41) | POLBLMNAKMT2ANPSR1MAPT | |
| SCHEMBL11552685 | 0.75 | NR4A2 (0.46) | POLBNR4A2RAB9ALMNAALDH1A1 | |
| SCHEMBL28553501 | 0.75 | KMT2A (0.61) | POLBNR4A2RAB9ALMNAALDH1A1 | |
| SCHEMBL11554724 | 0.74 | PRNP (0.45) | POLBRAB9AKMT2AMAPTNPC1 | |
| Hydrochloric Acid SCHEMBL11556095 | 0.74 | MAPT (0.51) | POLBNR4A2RAB9ALMNAALDH1A1 | |
| SCHEMBL11557882 | 0.74 | RAB9A (0.43) | POLBRAB9ALMNAKMT2AMAPT | |
| SCHEMBL11556308 | 0.74 | MMP2 (0.47) | POLBLMNAMAPTHTTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | claimed |
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |