Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Caffeic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 2/20 | 0.96 |
| ▸ | MMP1 known ✓ | P03956 | 2/20 | 0.96 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.96 |
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.96 |
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.96 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.96 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.96 |
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.96 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.96 |
| ▸ | HDAC7 known ✓ | Q8WUI4 | 1/20 | 0.96 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.96 |
| ▸ | HDAC10 known ✓ | Q969S8 | 1/20 | 0.96 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 1/20 | 0.96 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.96 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.96 |
| ▸ | HDAC9 known ✓ | Q9UKV0 | 1/20 | 0.96 |
| ▸ | HDAC5 known ✓ | Q9UQL6 | 1/20 | 0.96 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.67 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.59 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Caffeic Acid SCHEMBL1172851 | 1.00 | KDM4E (0.96) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL29353048 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL30501140 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL30050844 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL1262229 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL7064846 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL23358 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL3682144 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL21114743 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 | |
| Caffeic Acid SCHEMBL29447135 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11844820-B2 | Topical formulation and uses thereof | ARTHRITIS RELIEF PLUS LTD. (AU) | 2023-12-19 | — | — | US | disclosed |
| US-20190255133-A1 | TOPICAL FORMULATION AND USES THEREOF | ARTHRITIS RELIEF PLUS LTD. (AU) | 2019-08-22 | — | — | US | disclosed |
| US-10322155-B2 | Topical formulation and uses thereof | ARTHRITIS RELIEF PLUS LTD. (AU) | 2019-06-18 | — | — | US | disclosed |
| EP-3284470-A1 | TOPICAL FORMULATION COMPRISING COMFREY EXTRACT | Arthritis Relief Plus Ltd. (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-20110038965-A1 | TOPICAL FORMULATION AND USES THEREOF | ARTHRITIS RELIEF PLUS LTD. (AU) | 2011-02-17 | — | — | US | disclosed |
| EP-2086561-A1 | TOPICAL FORMULATION AND USES THEREOF | Arthritis Relief Plus Ltd. (AU) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008058333-A1 | TOPICAL FORMULATION AND USES THEREOF | ARTHRITIS RELIEF PLUS LTD (AU) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11844820-B2 | Topical formulation and uses thereof | SYMPK, MMP13, MMP7 | DPP4 2561/4885MMP1 23/4885MEN1 1977/4885 |
| US-20190255133-A1 | TOPICAL FORMULATION AND USES THEREOF | SYMPK, MMP13, MMP7 | DPP4 2561/4885MMP1 23/4885MEN1 1977/4885 |
| US-10322155-B2 | Topical formulation and uses thereof | SYMPK, MMP13, MMP7 | DPP4 2568/4885MMP1 28/4885MEN1 2227/4885 |
| US-20110038965-A1 | TOPICAL FORMULATION AND USES THEREOF | SYMPK, MMP13, MMP7 | DPP4 2561/4885MMP1 23/4885MEN1 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.