SCHEMBL120903

SCHEMBL120903

CC(=N)NC/C=C\CC[C@](C)(N)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GGT1 P19440 1/20 0.42
ARG1 P05089 1/20 0.39
ARG2 P78540 1/20 0.39
ACLY P53396 1/20 0.34
BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1843909 1.00 GGT1 (0.42) GGT1ARG1ARG2ACLYBLM
SCHEMBL909828 1.00 GGT1 (0.42) GGT1ARG1ARG2ACLYBLM
SCHEMBL2638239 1.00 GGT1 (0.42) GGT1ARG1ARG2ACLYBLM
SCHEMBL27626186 1.00 GGT1 (0.42) GGT1ARG1ARG2ACLYBLM
SCHEMBL6060538 1.00 GGT1 (0.42) GGT1ARG1ARG2ACLYBLM
SCHEMBL909829 1.00 GGT1 (0.42) GGT1ARG1ARG2ACLYBLM
Hydrochloric Acid SCHEMBL2713502 0.98 GGT1 (0.41) GGT1ARG1ARG2ACLYBLM
Hydrochloric Acid SCHEMBL6193942 0.98 GGT1 (0.41) GGT1ARG1ARG2ACLYBLM
Hydrochloric Acid SCHEMBL6193436 0.98 GGT1 (0.41) GGT1ARG1ARG2ACLYBLM
SCHEMBL6194043 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 776 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060123-A1 THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN LEVICEPT LTD (GB) 2021-03-04 US claimed
US-20180161392-A1 THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN LEVICEPT LTD (GB) 2018-06-14 US claimed
EP-2825208-B1 P75NTR NEUROTROPHIN BINDING PROTEIN FOR THERAPEUTIC USE LEVICEPT LTD (GB) 2017-05-17 EP claimed
US-20150037335-A1 THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN LEVICEPT LTD (GB) 2015-02-05 US claimed
EP-2175728-B1 SODIUM CHANNEL INHIBITORS ICAGEN INC (US) 2014-09-10 EP claimed
JP-4708024-B2 2011-06-22 JP claimed
US-20090111837-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PFIZER INC. 2009-04-30 US claimed
EP-1855686-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN Pfizer Limited (GB) 2007-11-21 EP claimed
WO-2006092691-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PFIZER LIMITED (GB) 2006-09-08 WO claimed
US-6951889-B2 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors PHARMACIA CORPORATION (US) 2005-10-04 US claimed
EP-1317421-B1 2-AMINO-2-ALKYL-5 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS PHARMACIA CORP (US) 2005-02-23 EP claimed
EP-1506040-A2 SELECTIVE INOS INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES AND CONDITIONS Pharmacia Corporation (US) 2005-02-16 EP claimed
US-20040225150-A1 Methods for selectively removing counterions from compounds and compounds derived from such methods PHARMACIA & UPJOHN COMPANY 2004-11-11 US claimed
US-20040132822-A1 Crystalline solid form of (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid PHARMACIA LLC 2004-07-08 US claimed
US-20040077639-A1 Methods for the treatment of respiratory diseases and conditions using a selective iNOS inhibitor MANNING PAMELA T (US) 2004-04-22 US claimed
WO-2004018412-A1 CRYSTALLINE SOLID FORM OF (2S-5Z)-2-AMINO-7-(ETHANIMIDOYLAMINO)-2-METHYLHEPT-5-ENOIC ACID PHARMACIA CORPORATION (US) 2004-03-04 WO claimed
WO-2003097163-A2 USING A SELECTIVE INOS INHIBITOR FOR THE TREATMENT OF RESPIRATORY DISEASES AND CONDITIONS PHARMACIA CORPORATION (US) 2003-11-27 WO claimed
EP-1317421-A1 2-AMINO-2-ALKYL-5 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS Pharmacia Corporation (US) 2003-06-11 EP claimed
US-20020132849-A1 2-Amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors PHARMACIA LLC 2002-09-19 US claimed
WO-2002022562-A1 2-AMINO-2-ALKYL-5 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS PHARMACIA CORPORATION (US) 2002-03-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040132822-A1 Crystalline solid form of (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid SLC7A5, SLC6A15, METTL14 GGT1 3674/4885ARG1 2930/4885ARG2 3737/4885
US-20040077639-A1 Methods for the treatment of respiratory diseases and conditions using a selective iNOS inhibitor NOS2, NOS1, NOS3 GGT1 205/4885ARG1 9/4885ARG2 4/4885
US-20040225150-A1 Methods for selectively removing counterions from compounds and compounds derived from such methods BHMT2, MGMT, BHMT GGT1 355/4885ARG1 1652/4885ARG2 363/4885
US-20020132849-A1 2-Amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors PTGIS, ALOX5, ALOX15 GGT1 803/4885ARG1 583/4885ARG2 275/4885
US-20090111837-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PDE7A, PDE7B, PDE3A GGT1 860/4885ARG1 3985/4885ARG2 3210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.