SCHEMBL12405754

SCHEMBL12405754

C[Si](C)(C)O[Si](C)(CCCCCCCCCCC(=O)O)O[Si](C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.48
LMNA P02545 2/20 0.48
NFKB1 P19838 1/20 0.48
PMP22 Q01453 1/20 0.48
ALDH1A1 P00352 3/20 0.45
GPR84 Q9NQS5 8/20 0.45
PPARG P37231 7/20 0.45
PPARD Q03181 7/20 0.45
PPARA Q07869 7/20 0.45
HDAC11 Q96DB2 5/20 0.45
PTPN1 P18031 3/20 0.45
TLR2 O60603 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
FABP4 P15090 2/20 0.45
FFAR1 O14842 2/20 0.45
FFAR4 Q5NUL3 2/20 0.45
SLC22A6 Q4U2R8 1/20 0.45
SLC22A8 Q8TCC7 1/20 0.45
MEN1 O00255 1/20 0.45
ESR1 P03372 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL786856 0.93 TSHR (0.41) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL12405769 0.93 TSHR (0.41) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL29728655 0.92 LMNA (0.42) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL1048691 0.84 TSHR (0.48) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL17088168 0.83 AKR1B1 (0.42) TSHRLMNAALDH1A1GPR84PPARG
SCHEMBL13038577 0.82 LMNA (0.37) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL8674170 0.82 LMNA (0.46) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL3504025 0.82 ALDH1A1 (0.52) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL17035392 0.81 TSHR (0.44) TSHRLMNANFKB1PMP22ALDH1A1
SCHEMBL17736531 0.81 DGKA (0.33) TSHRLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210085592-A1 THICKENER FOR NON-AQUEOUS SYSTEMS, AND THICKENER COMPOSITION SHISEIDO COMPANY, LTD. (JP) 2021-03-25 US claimed
EP-3677655-A1 THICKENER FOR NON-AQUEOUS SYSTEMS, AND THICKENER COMPOSITION Shiseido Company, Ltd. (JP) 2020-07-08 EP claimed
CN-111032815-A Nonaqueous thickener and thickening composition 株式会社资生堂 2020-04-17 CN claimed
EP-2777690-B1 OIL-IN-WATER TYPE EMULSIFIED SUNSCREEN COSMETIC SHISEIDO CO LTD (JP) 2017-06-21 EP claimed
CN-103974692-B Oil-in-water emulsion type sunscreen preparation SHISEIDO CO.,LTD. (JP) 2016-04-20 CN claimed
US-20150157546-A1 OIL-IN-WATER TYPE EMULSIFIED SUNSCREEN COSMETIC SHISEIDO COMPANY, LTD. (JP) 2015-06-11 US claimed
EP-2777690-A1 OIL-IN-WATER TYPE EMULSIFIED SUNSCREEN COSMETIC Shiseido Company, Ltd. (JP) 2014-09-17 EP claimed
CN-103974692-A Oil-in-water type emulsified sunscreen cosmetic SHISEDO CO LTD 2014-08-06 CN claimed
EP-3195932-B1 HYDROSILYLATION REACTION CATALYST UNIV KYUSHU NAT UNIV CORP (JP) 2024-08-21 EP disclosed
EP-3181226-B1 HYDROSILYLATION REACTION CATALYST UNIV KYUSHU NAT UNIV CORP (JP) 2024-08-07 EP disclosed
EP-3323505-B1 HYDROSILYLATION REACTION CATALYST UNIV KYUSHU NAT UNIV CORP (JP) 2024-07-17 EP disclosed
US-20230372228-A1 CARBOXYLIC ACID CO-MODIFIED ORGANOPOLYSILOXANE AND USE THEREOF DOW TORAY CO., LTD. (JP) 2023-11-23 US disclosed
EP-3213742-B1 WATER-IN-OIL EMULSION SUNSCREEN COSMETIC SHISEIDO CO LTD (JP) 2023-09-06 EP disclosed
US-20230142992-A1 THICKENER FOR NON-AQUEOUS COMPOSITIONS SHISEIDO COMPANY, LTD. (JP) 2023-05-11 US disclosed
EP-2808008-A1 WATER-IN-OIL-TYPE EMULSION SKIN COSMETIC Shiseido Company, Ltd. (JP) 2014-12-03 EP disclosed
US-20140348765-A1 Water-in-Oil Emulsified Skin Cosmetic SHISEIDO COMPANY, LTD. (JP) 2014-11-27 US disclosed
EP-2777690-A1 OIL-IN-WATER TYPE EMULSIFIED SUNSCREEN COSMETIC Shiseido Company, Ltd. (JP) 2014-09-17 EP disclosed
CN-103974692-A Oil-in-water type emulsified sunscreen cosmetic SHISEDO CO LTD 2014-08-06 CN disclosed
US-20110182846-A1 Surface Treating Agent, Surface-Treated Powder, And Cosmetic SHISEIDO COMPANY LTD. (JP) 2011-07-28 US disclosed
US-20110135585-A1 Complex, Emulsion Containing The Same, And Water-In-Oil Emulsion Cosmetic Containing The Same SHISEIDO COMPANY, LTD. (JP) 2011-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230372228-A1 CARBOXYLIC ACID CO-MODIFIED ORGANOPOLYSILOXANE AND USE THEREOF H1-0, COL1A1, COL2A1 TSHR 2613/4885LMNA 3838/4885NFKB1 3857/4885
US-20110135585-A1 Complex, Emulsion Containing The Same, And Water-In-Oil Emulsion Cosmetic Containing The Same SQLE, CUTA, FDFT1 TSHR 3776/4885LMNA 1471/4885NFKB1 1454/4885
US-20110182846-A1 Surface Treating Agent, Surface-Treated Powder, And Cosmetic CUTA, DSG1, TYR TSHR 217/4885LMNA 3637/4885NFKB1 3674/4885
US-20140348765-A1 Water-in-Oil Emulsified Skin Cosmetic CUTA, SQLE, DEGS1 TSHR 869/4885LMNA 3705/4885NFKB1 1546/4885
US-20210085592-A1 THICKENER FOR NON-AQUEOUS SYSTEMS, AND THICKENER COMPOSITION DSG1, AQP1, AQP3 TSHR 3759/4885LMNA 3127/4885NFKB1 4069/4885
US-20230142992-A1 THICKENER FOR NON-AQUEOUS COMPOSITIONS DSG1, AQP1, STOM TSHR 4109/4885LMNA 3537/4885NFKB1 3913/4885
US-20150157546-A1 OIL-IN-WATER TYPE EMULSIFIED SUNSCREEN COSMETIC POLQ, RECQL, SQLE TSHR 2639/4885LMNA 1113/4885NFKB1 2038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.