Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 4/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.50 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.39 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7806641 | 0.84 | CA12 (0.57) | CA12CA9CA2ALDH1A1ALOX15 | |
| SCHEMBL30882073 | 0.76 | ALDH1A1 (0.56) | CA12CA9CA2ALDH1A1ALOX15 | |
| SCHEMBL16968444 | 0.74 | ALDH1A1 (0.48) | ALDH1A1ALOX15TSHRRAB9AHPGD | |
| SCHEMBL27273951 | 0.74 | RAB9A (0.48) | CA12CA9CA2ALDH1A1ALOX15 | |
| Sulfuric Acid SCHEMBL4958447 | 0.74 | HPGD (0.54) | CA12CA9CA2ALDH1A1ALOX15 | |
| Water SCHEMBL10540128 | 0.73 | ALDH1A1 (0.59) | CA12CA9CA2ALDH1A1ALOX15 | |
| SCHEMBL16187039 | 0.73 | — | — | |
| SCHEMBL21208167 | 0.73 | ALDH1A1 (0.67) | CA12CA9CA2ALDH1A1ALOX15 | |
| SCHEMBL8277 | 0.73 | — | — | |
| SCHEMBL7879117 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108916-A1 | METHOD OF USING ULTRASONIC VIBRATION TO SECURE BODY TISSUE WITH FASTENING ELEMENT | STARBOARD VALUE INTERMEDIATE FUND LP, AS COLLATERAL AGENT | 2008-05-08 | — | — | US | claimed |
| US-4915944-A | PROTECTIVE AGAINST SOIL-BORNE PHYTOPATHOGENS | YISSUM RESEARCH DEVELOPMENT CORP. OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1990-04-10 | — | — | US | claimed |
| EP-0133878-B1 | NOVEL ISOLATES OF TRICHODERMA, FUNGICIDAL COMPOSITIONS CONTAINING SAID ISOLATES AND USE THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1990-03-14 | — | — | EP | claimed |
| US-4713342-A | Novel isolate of trichoderma, fungicidal compositions containing said isolate and use thereof | YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1987-12-15 | — | — | US | claimed |
| EP-0133878-A1 | Novel isolates of trichoderma, fungicidal compositions containing said isolates and use thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1985-03-13 | — | — | EP | claimed |
| US-20190298331-A1 | METHOD AND DEVICE FOR SECURING BODY TISSUE | P TECH, LLC | 2019-10-03 | — | — | US | disclosed |
| US-20180368826-A1 | DEVICE AND METHOD FOR SECURING BODY TISSUE | MARCTEC, LLC | 2018-12-27 | — | — | US | disclosed |
| US-9986994-B2 | Method and device for securing body tissue | P TECH, LLC (US) | 2018-06-05 | — | — | US | disclosed |
| US-9980717-B2 | Device and method for securing body tissue | P TECH, LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-20180132844-A1 | METHOD AND DEVICE FOR SECURING BODY TISSUE | BONUTTI 2003 TRUST | 2018-05-17 | — | — | US | disclosed |
| US-20180133974-A1 | METHOD OF USING ULTRASONIC VIBRATION TO SECURE BODY TISSUE | BONUTTI, PETER M | 2018-05-17 | — | — | US | disclosed |
| US-9888916-B2 | Method and device for securing body tissue | P TECH, LLC (US) | 2018-02-13 | — | — | US | disclosed |
| US-3981860-A | PLANT GROWTH REGULATORS, HERBICIDES | HOFFMANN-LA ROCHE INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3961050-A | Insecticidal compositions and methods of killing insects using benzylthiomethylenephosphonamidates and phosphoramidates | VELSICOL CHEMICAL CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |
| US-3959478-A | Insecticidal 2-phenyl-4-benzoyl-1,2,4-oxadiazolidine-3,5-diones | VELSICOL CHEMICAL CORPORATION (US) | 1976-05-25 | — | — | US | disclosed |
| US-3958007-A | FUNGICIDES, MITE OVICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-05-18 | — | — | US | disclosed |
| US-3950391-A | FUNGICIDES, MITICIDES, OVICIDES | ADAMS CHARLES D | 1976-04-13 | — | — | US | disclosed |
| US-3948967-A | HERBICIDE, FUNGICIDE | VELSICOL CHEMICAL CORPORATION (US) | 1976-04-06 | — | — | US | disclosed |
| US-3937824-A | COMPOSITIONS AND METHODS OF KILLING INSECTS AND ACARIDS USING ALKOXYIMINO CARBAMOYLOXY PHOSPHORUS COMPOUNDS | VELSICOL CHEMICAL CORPORATION (US) | 1976-02-10 | — | — | US | disclosed |
| US-3931149-A | PLANT GROWTH REGULATORS | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |